Cell atlas - ARHGEF15 - The Human Protein Atlas

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ARHGEF15

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ARHGEF15
Gene description	Rho guanine nucleotide exchange factor (GEF) 15
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Group enriched (TIME, HUVEC TERT2)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA044443 , HPA063495
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (TIME, HUVEC TERT2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044443	HUVEC TERT2	Plasma membrane	Intensity
	HPA063495	HUVEC TERT2	Nucleoplasm
	HPA063495	HUVEC TERT2	Plasma membrane

GENE INFORMATION
Gene name	ARHGEF15 (HGNC Symbol)
Synonyms	ARGEF15, FLJ13791, KIAA0915, MGC44868, Vsm-RhoGEF
Description	Rho guanine nucleotide exchange factor (GEF) 15 (HGNC Symbol)
Entrez gene summary	Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	8310241 - 8322516
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198844 (version 83.38)
Entrez gene	22899
UniProt	O94989 (UniProt - Evidence at protein level)
neXtProt	NX_O94989
Antibodypedia	ARHGEF15 antibodies

PROTEIN BROWSER

ARHGEF15-001	ARHGEF15-004	ARHGEF15-005	ARHGEF15-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF15-001 ENSP00000355026 ENST00000361926	O94989 [Direct mapping] Rho guanine nucleotide exchange factor 15 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0030425 [dendrite] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0050790 [regulation of catalytic activity] GO:0051496 [positive regulation of stress fiber assembly] GO:0061299 [retina vasculature morphogenesis in camera-type eye] GO:2000297 [negative regulation of synapse maturation] Show all	841 aa 91.9 kDa	No	0
ARHGEF15-004 ENSP00000464540 ENST00000579439	J3QS60 [Direct mapping] Rho guanine nucleotide exchange factor 15 Show all	Predicted intracellular proteins Show all		208 aa 21.1 kDa	No	0
ARHGEF15-005 ENSP00000462796 ENST00000583529	J3KT46 [Direct mapping] Rho guanine nucleotide exchange factor 15 Show all	Predicted intracellular proteins Show all		116 aa 12.1 kDa	No	0
ARHGEF15-201 ENSP00000412505 ENST00000421050	O94989 [Direct mapping] Rho guanine nucleotide exchange factor 15 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0030425 [dendrite] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0050790 [regulation of catalytic activity] GO:0051496 [positive regulation of stress fiber assembly] GO:2000297 [negative regulation of synapse maturation] Show all	841 aa 91.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.