Tissue expression of ARHGEF15 - Summary - The Human Protein Atlas

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ARHGEF15

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ARHGEF15
Gene description	Rho guanine nucleotide exchange factor (GEF) 15
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adipose tissue)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044443
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ARHGEF15 (HGNC Symbol)
Synonyms	ARGEF15, FLJ13791, KIAA0915, MGC44868, Vsm-RhoGEF
Description	Rho guanine nucleotide exchange factor (GEF) 15 (HGNC Symbol)
Entrez gene summary	Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	8310241 - 8322516
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198844 (version 83.38)
Entrez gene	22899
UniProt	O94989 (UniProt - Evidence at protein level)
neXtProt	NX_O94989
Antibodypedia	ARHGEF15 antibodies

PROTEIN BROWSER

ARHGEF15-001	ARHGEF15-004	ARHGEF15-005	ARHGEF15-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF15-001 ENSP00000355026 ENST00000361926	O94989 [Direct mapping] Rho guanine nucleotide exchange factor 15 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0030425 [dendrite] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0050790 [regulation of catalytic activity] GO:0051496 [positive regulation of stress fiber assembly] GO:0061299 [retina vasculature morphogenesis in camera-type eye] GO:2000297 [negative regulation of synapse maturation] Show all	841 aa 91.9 kDa	No	0
ARHGEF15-004 ENSP00000464540 ENST00000579439	J3QS60 [Direct mapping] Rho guanine nucleotide exchange factor 15 Show all	Predicted intracellular proteins Show all		208 aa 21.1 kDa	No	0
ARHGEF15-005 ENSP00000462796 ENST00000583529	J3KT46 [Direct mapping] Rho guanine nucleotide exchange factor 15 Show all	Predicted intracellular proteins Show all		116 aa 12.1 kDa	No	0
ARHGEF15-201 ENSP00000412505 ENST00000421050	O94989 [Direct mapping] Rho guanine nucleotide exchange factor 15 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0030425 [dendrite] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0050790 [regulation of catalytic activity] GO:0051496 [positive regulation of stress fiber assembly] GO:2000297 [negative regulation of synapse maturation] Show all	841 aa 91.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.