Cell atlas - RBM20 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RBM20
Gene description	RNA binding motif protein 20
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the nucleus, nucleoli & cytokinetic bridge.
RNA cell category	Cell line enhanced (SH-SY5Y, RH-30, T-47d)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved)
Additional location	In addition localized to the Nucleus (approved), Nucleoli (approved), Cytokinetic bridge (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035806
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, RH-30, T-47d) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the nucleus, nucleoli & cytokinetic bridge.

Main location

Golgi apparatus (approved)

Additional location

Nucleus (approved), Nucleoli (approved), Cytokinetic bridge (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA035806	RH-30	Nucleus
HPA035806	RH-30	Golgi apparatus
HPA035806	U-2 OS	Nucleoli
		Golgi apparatus
		Cytokinetic bridge	Intensity	Intensity
HPA035806	U-251 MG	No staining

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	RBM20
Synonyms
Description	RNA binding motif protein 20 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that binds RNA and regulates splicing. Mutations in this gene have been associated with familial dilated cardiomyopathy. [provided by RefSeq, Apr 2014]
Chromosome	10
Cytoband	q25.2
Chromosome location (bp)	110644397 - 110839469
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203867 (version 83.38)
Entrez gene	282996
UniProt	Q5T481 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T481
Antibodypedia	RBM20 antibodies

PROTEIN BROWSER

RBM20-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RBM20-001 ENSP00000358532 ENST00000369519	Q5T481 [Direct mapping] RNA-binding protein 20 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0006397 [mRNA processing] GO:0007507 [heart development] GO:0008270 [zinc ion binding] GO:0008380 [RNA splicing] GO:0033120 [positive regulation of RNA splicing] Show all	1227 aa 134.3 kDa	No	0