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TRIM15

GENERAL INFORMATION

Gene name

 TRIM15

Gene description

 Tripartite motif containing 15

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (duodenum, colon)
GTEx:Group enriched (small intestine, colon, liver, kidney)
FANTOM5:Tissue enhanced (small intestine, gallbladder, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA047527
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (duodenum, colon)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon, liver, kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, gallbladder, colon)

GENE INFORMATION

Gene name

 TRIM15 (HGNC Symbol)

Synonyms

 RNF93, ZNF178, ZNFB7

Description

 Tripartite motif containing 15 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p22.1

Chromosome location (bp)

 30163206 - 30172696

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204610 (version 83.38)

Entrez gene

 89870

UniProt

 Q9C019 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9C019

Antibodypedia

 TRIM15 antibodies

PROTEIN BROWSER
TRIM15-001
TRIM15-002
TRIM15-202
TRIM15-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIM15-001
ENSP00000365884
ENST00000376694
Q9C019 [Direct mapping]
Tripartite motif-containing protein 15
Q5SRL0 [Target identity:100%; Query identity:100%]
Tripartite motif-containing 15; cDNA FLJ75016, highly similar to Homo sapiens tripartite motif-containing 15 (TRIM15), transcript variant 1, mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007500 [mesodermal cell fate determination]
GO:0008270 [zinc ion binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:1900246 [positive regulation of RIG-I signaling pathway]
GO:1901253 [negative regulation of intracellular transport of viral material]
GO:1902187 [negative regulation of viral release from host cell]
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 465 aa
52.1 kDa 		No 0
TRIM15-002
ENSP00000398285
ENST00000433744
H0Y5R0 [Direct mapping]
Tripartite motif-containing protein 15
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Predicted intracellular proteins
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 164 aa
19.2 kDa 		No 0
TRIM15-202
ENSP00000365878
ENST00000376688
Q9C019 [Direct mapping]
Tripartite motif-containing protein 15
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Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007500 [mesodermal cell fate determination]
GO:0008270 [zinc ion binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:1900246 [positive regulation of RIG-I signaling pathway]
GO:1901253 [negative regulation of intracellular transport of viral material]
GO:1902187 [negative regulation of viral release from host cell]
Show all
 115 aa
12.3 kDa 		No 0
TRIM15-203
ENSP00000484001
ENST00000619857
A0A087X199 [Direct mapping]
Tripartite motif-containing protein 15
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Predicted intracellular proteins
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GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
Show all
 396 aa
44.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.