Cell atlas - IGFL2 - The Human Protein Atlas

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IGFL2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	IGFL2
Gene description	IGF-like family member 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.
RNA cell category	Cell line enriched (CACO-2)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA059137
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.

Main location

Nucleoplasm (approved)

Additional location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059137	CACO-2	Nucleoplasm
	HPA059137	SiHa	Nucleoplasm
	HPA059137	SiHa	Plasma membrane

GENE INFORMATION
Gene name	IGFL2 (HGNC Symbol)
Synonyms	UNQ645
Description	IGF-like family member 2 (HGNC Symbol)
Entrez gene summary	IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	46143106 - 46161299
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000204866 (version 83.38)
Entrez gene	147920
UniProt	Q6UWQ7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6UWQ7
Antibodypedia	IGFL2 antibodies

PROTEIN BROWSER

IGFL2-001	IGFL2-002	IGFL2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGFL2-001 ENSP00000395219 ENST00000434646	Q6UWQ7 [Direct mapping] Insulin growth factor-like family member 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] Show all	130 aa 14.5 kDa	Yes	0
IGFL2-002 ENSP00000366922 ENST00000377693	Q6UWQ7 [Direct mapping] Insulin growth factor-like family member 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] Show all	119 aa 13.2 kDa	Yes	0
IGFL2-006 ENSP00000471085 ENST00000601052	M0R089 [Direct mapping] Insulin growth factor-like family member 2 Show all	Predicted intracellular proteins Show all		84 aa 9.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.