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KRT25

GENERAL INFORMATION

Gene name

 KRT25

Gene description

 Keratin 25, type I

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (breast, testis)
GTEx:Tissue enriched (skin)
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Highly expressed in the internal root sheath of hair follicles.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA053977 , HPA058943
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Hair
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Hair

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (breast, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 KRT25 (HGNC Symbol)

Synonyms

 KRT25A

Description

 Keratin 25, type I (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 40748021 - 40755332

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204897 (version 83.38)

Entrez gene

 147183

UniProt

 Q7Z3Z0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z3Z0

Antibodypedia

 KRT25 antibodies

PROTEIN BROWSER
KRT25-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT25-001
ENSP00000310573
ENST00000312150
Q7Z3Z0 [Direct mapping]
Keratin, type I cytoskeletal 25
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0007568 [aging]
GO:0031069 [hair follicle morphogenesis]
GO:0042633 [hair cycle]
GO:0045109 [intermediate filament organization]
GO:0070062 [extracellular exosome]
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 450 aa
49.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.