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Moderate cytoplasmic positivity was observed in a small subset of tumor cells in a few cases of testis cancer. Remaining cancer tissues were mainly negative.
GENE INFORMATION
Gene name
GAGE1 (HGNC Symbol)
Synonyms
CT4.1
Description
G antigen 1 (HGNC Symbol)
Entrez gene summary
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. Nothing is presently known about the function of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
