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A few lung cancers showed moderate cytoplasmic and/or nuclear staining in a fraction of tumor cells. Rare case of urothelial and liver cancer displayed moderate staining. Remaining malignant tissues were negative.
Malignant cells displayed weak to moderate cytoplasmic immunoreactivity and additional nuclear positivity in a few cases. Several breast and prostate cancers were strongly stained. Several cervical, skin, testicular and urothelial cancers were negative.
A few renal cancers displayed strong cytoplasmic while a fraction of tumor cells in a few endometrial cancers exhibited moderate granular cytoplasmic positivity. Remaining cancer cells were negative.
Most cancer tissues showed weak to moderate cytoplasmic staining with additional nuclear positivity in several cases. Several gliomas, lymphomas, melanomas, lung and renal cell carcinomas were negative.
Most cancer tissues showed weak to moderate nuclear immunoreactivity with additional cytoplasmic positivity in a few cases. Occasional pancreatic cancers were strongly stained. Gliomas, non-Hodgkin's lymphomas, testicular, renal breast and prostate cancers were generally negative.
GENE INFORMATION
Gene name
TCEB3B (HGNC Symbol)
Synonyms
HsT832, TCEB3L
Description
Transcription elongation factor B polypeptide 3B (elongin A2) (HGNC Symbol)
Entrez gene summary
This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]
