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TCEB3B

GENERAL INFORMATION

Gene name

 TCEB3B

Gene description

 Transcription elongation factor B polypeptide 3B (elongin A2)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 5 antibodies.
HPA041009 , HPA043501 , HPA048971 , HPA049178 , HPA050086
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 TCEB3B (HGNC Symbol)

Synonyms

 HsT832, TCEB3L

Description

 Transcription elongation factor B polypeptide 3B (elongin A2) (HGNC Symbol)

Entrez gene summary

 This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q21.1

Chromosome location (bp)

 47032572 - 47035621

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000206181 (version 83.38)

Entrez gene

 51224

UniProt

 Q8IYF1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IYF1

Antibodypedia

 TCEB3B antibodies

PROTEIN BROWSER
TCEB3B-001
TCEB3B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCEB3B-001
ENSP00000331302
ENST00000332567
Q8IYF1 [Direct mapping]
RNA polymerase II transcription factor SIII subunit A2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0016021 [integral component of membrane]
GO:0032784 [regulation of DNA-templated transcription, elongation]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0070449 [elongin complex]
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 753 aa
83.9 kDa 		No 0
TCEB3B-201
ENSP00000479491
ENST00000620522
A0A087WVK4 [Direct mapping]
RNA polymerase II transcription factor SIII subunit A2
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0016021 [integral component of membrane]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0070449 [elongin complex]
Show all
 546 aa
60.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.