Expression of TSN in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Translin

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA059561

GENE INFORMATION
Gene name	TSN (HGNC Symbol)
Synonyms	BCLF-1, REHF-1, TRSLN
Description	Translin (HGNC Symbol)
Entrez gene summary	This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Chromosome	2
Cytoband	q14.3
Chromosome location (bp)	121737103 - 121767853
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000211460 (version 83.38)
Entrez gene	7247
UniProt	Q15631 (UniProt - Evidence at protein level)
neXtProt	NX_Q15631
Antibodypedia	TSN antibodies

PROTEIN BROWSER

TSN-001	TSN-007	TSN-008	TSN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSN-001 ENSP00000374332 ENST00000389682	Q15631 [Direct mapping] Translin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003697 [single-stranded DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0004521 [endoribonuclease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006310 [DNA recombination] GO:0010467 [gene expression] GO:0031047 [gene silencing by RNA] GO:0043565 [sequence-specific DNA binding] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	228 aa 26.2 kDa	No	0
TSN-007 ENSP00000387263 ENST00000409193	E9PGT1 [Direct mapping] Translin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003697 [single-stranded DNA binding] GO:0004521 [endoribonuclease activity] GO:0005737 [cytoplasm] GO:0043565 [sequence-specific DNA binding] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	223 aa 25.6 kDa	No	0
TSN-008 ENSP00000399735 ENST00000455432	H7C1D4 [Direct mapping] Translin Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003697 [single-stranded DNA binding] GO:0004521 [endoribonuclease activity] GO:0005737 [cytoplasm] GO:0043565 [sequence-specific DNA binding] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	185 aa 21 kDa	No	0
TSN-201 ENSP00000437728 ENST00000536142	Q15631 [Direct mapping] Translin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003697 [single-stranded DNA binding] GO:0004521 [endoribonuclease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006310 [DNA recombination] GO:0010467 [gene expression] GO:0031047 [gene silencing by RNA] GO:0043565 [sequence-specific DNA binding] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	148 aa 17.3 kDa	No	1