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TSN

GENERAL INFORMATION

Gene name

 TSN

Gene description

 Translin

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in several tissues, including testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA059561
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TSN (HGNC Symbol)

Synonyms

 BCLF-1, REHF-1, TRSLN

Description

 Translin (HGNC Symbol)

Entrez gene summary

 This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Chromosome

 2

Cytoband

 q14.3

Chromosome location (bp)

 121737103 - 121767853

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000211460 (version 83.38)

Entrez gene

 7247

UniProt

 Q15631 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15631

Antibodypedia

 TSN antibodies

PROTEIN BROWSER
TSN-001
TSN-007
TSN-008
TSN-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TSN-001
ENSP00000374332
ENST00000389682
Q15631 [Direct mapping]
Translin
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0004521 [endoribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006310 [DNA recombination]
GO:0010467 [gene expression]
GO:0031047 [gene silencing by RNA]
GO:0043565 [sequence-specific DNA binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 228 aa
26.2 kDa 		No 0
TSN-007
ENSP00000387263
ENST00000409193
E9PGT1 [Direct mapping]
Translin
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003697 [single-stranded DNA binding]
GO:0004521 [endoribonuclease activity]
GO:0005737 [cytoplasm]
GO:0043565 [sequence-specific DNA binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 223 aa
25.6 kDa 		No 0
TSN-008
ENSP00000399735
ENST00000455432
H7C1D4 [Direct mapping]
Translin
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003697 [single-stranded DNA binding]
GO:0004521 [endoribonuclease activity]
GO:0005737 [cytoplasm]
GO:0043565 [sequence-specific DNA binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 185 aa
21 kDa 		No 0
TSN-201
ENSP00000437728
ENST00000536142
Q15631 [Direct mapping]
Translin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0004521 [endoribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006310 [DNA recombination]
GO:0010467 [gene expression]
GO:0031047 [gene silencing by RNA]
GO:0043565 [sequence-specific DNA binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 148 aa
17.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.