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AS3MT

GENERAL INFORMATION

Gene name

 AS3MT

Gene description

 Arsenite methyltransferase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (adrenal gland, parathyroid gland)
GTEx:Tissue enriched (adrenal gland)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in adrenal gland.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA017856 , HPA027708
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 AS3MT (HGNC Symbol)

Synonyms

 CYT19

Description

 Arsenite methyltransferase (HGNC Symbol)

Entrez gene summary

 AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]

Chromosome

 10

Cytoband

 q24.32

Chromosome location (bp)

 102869516 - 102901899

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000214435 (version 83.38)

Entrez gene

 57412

UniProt

 Q9HBK9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HBK9

Antibodypedia

 AS3MT antibodies

PROTEIN BROWSER
AS3MT-001
AS3MT-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AS3MT-001
ENSP00000358896
ENST00000369880
Q9HBK9 [Direct mapping]
Arsenite methyltransferase
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006805 [xenobiotic metabolic process]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0009404 [toxin metabolic process]
GO:0018872 [arsonoacetate metabolic process]
GO:0030791 [arsenite methyltransferase activity]
GO:0030792 [methylarsonite methyltransferase activity]
GO:0032259 [methylation]
GO:0044281 [small molecule metabolic process]
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 375 aa
41.7 kDa 		No 0
AS3MT-201
ENSP00000479361
ENST00000615257
A0A087WVD4 [Direct mapping]
Arsenite methyltransferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0032259 [methylation]
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 338 aa
38 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.