We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Majority cancer tissues showed weak to moderate cytoplasmic and occasional nuclear staining. Occasional cases of basal cell carcinomas of skin displayed strong positivity. Lymphomas, liver and stomach cancers were negative.
Most cancer tissues showed moderate to strong cytoplasmic and nuclear positivity. Pancreatic, testis and thyroid cancers were weakly stained or negative.
GENE INFORMATION
Gene name
PPME1 (HGNC Symbol)
Synonyms
PME-1
Description
Protein phosphatase methylesterase 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Q9Y570 [Direct mapping] Protein phosphatase methylesterase 1
Show all
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004864 [protein phosphatase inhibitor activity] GO:0006482 [protein demethylation] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0019903 [protein phosphatase binding] GO:0034047 [regulation of protein phosphatase type 2A activity] GO:0043086 [negative regulation of catalytic activity] GO:0051721 [protein phosphatase 2A binding] GO:0051722 [protein C-terminal methylesterase activity] GO:0052689 [carboxylic ester hydrolase activity]
