Cell atlas - PPME1 - The Human Protein Atlas

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PPME1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PPME1
Gene description	Protein phosphatase methylesterase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB004541 , HPA064396
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB004541	A-431	Nucleus	Intensity
	CAB004541	U-2 OS	Nucleus	Intensity
	CAB004541	U-251 MG	Nucleoplasm
	HPA064396	CACO-2	Nucleoplasm
	HPA064396	CACO-2	Nuclear bodies
	HPA064396	RH-30	Nucleoplasm	Intensity
	HPA064396	U-2 OS	No staining

GENE INFORMATION
Gene name	PPME1 (HGNC Symbol)
Synonyms	PME-1
Description	Protein phosphatase methylesterase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	74171099 - 74254703
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000214517 (version 83.38)
Entrez gene	51400
UniProt	Q9Y570 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y570
Antibodypedia	PPME1 antibodies

PROTEIN BROWSER

PPME1-001	PPME1-002	PPME1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPME1-001 ENSP00000329867 ENST00000328257	Q9Y570 [Direct mapping] Protein phosphatase methylesterase 1 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0006482 [protein demethylation] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0019903 [protein phosphatase binding] GO:0034047 [regulation of protein phosphatase type 2A activity] GO:0043086 [negative regulation of catalytic activity] GO:0051721 [protein phosphatase 2A binding] GO:0051722 [protein C-terminal methylesterase activity] GO:0052689 [carboxylic ester hydrolase activity] Show all	386 aa 42.3 kDa	No	0
PPME1-002 ENSP00000381461 ENST00000398427	Q9Y570 [Direct mapping] Protein phosphatase methylesterase 1 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0006482 [protein demethylation] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0034047 [regulation of protein phosphatase type 2A activity] GO:0043086 [negative regulation of catalytic activity] GO:0051721 [protein phosphatase 2A binding] GO:0051722 [protein C-terminal methylesterase activity] GO:0052689 [carboxylic ester hydrolase activity] Show all	400 aa 43.9 kDa	No	0
PPME1-201 ENSP00000484654 ENST00000617237	A0A0C4DH02 [Direct mapping] Protein phosphatase methylesterase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		135 aa 15.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.