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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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PHB2
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PHB2

Gene description

Prohibitin 2

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA039874 , CAB014889 , CAB026335
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin050100150200250300TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin050100150200RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200250300350Tags Per Million

GENE INFORMATION

Gene name

PHB2 (HGNC Symbol)

Synonyms

Bap37, BCAP37, p22, REA

Description

Prohibitin 2 (HGNC Symbol)

Entrez gene summary

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6965327 - 6970825

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000215021 (version 83.38)

Entrez gene

11331

UniProt

Q99623 (UniProt - Evidence at protein level)

neXtProt

NX_Q99623

Antibodypedia

PHB2 antibodies

PROTEIN BROWSER

PHB2-001
PHB2-003
PHB2-006
PHB2-008
PHB2-010
PHB2-012
PHB2-201
PHB2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHB2-001
ENSP00000441875
ENST00000535923
Q99623 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007005 [mitochondrion organization]
GO:0007062 [sister chromatid cohesion]
GO:0008022 [protein C-terminus binding]
GO:0009986 [cell surface]
GO:0016363 [nuclear matrix]
GO:0030331 [estrogen receptor binding]
GO:0031536 [positive regulation of exit from mitosis]
GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway]
GO:0033218 [amide binding]
GO:0033600 [negative regulation of mammary gland epithelial cell proliferation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060744 [mammary gland branching involved in thelarche]
GO:0060749 [mammary gland alveolus development]
GO:0060762 [regulation of branching involved in mammary gland duct morphogenesis]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
Show all
299 aa
33.3 kDa
No 0
PHB2-003
ENSP00000440317
ENST00000542912
F5GY37 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
267 aa
29.7 kDa
No 0
PHB2-006
ENSP00000441662
ENST00000545167
F5GWA7 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
261 aa
29.2 kDa
No 0
PHB2-008
ENSP00000438634
ENST00000546111
F5H2D2 [Direct mapping]
Prohibitin-2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
87 aa
9.3 kDa
No 0
PHB2-010
ENSP00000475382
ENST00000545555
U3KPZ5 [Direct mapping]
Prohibitin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
103 aa
11.1 kDa
No 0
PHB2-012
ENSP00000439029
ENST00000536316
F5H3X6 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
213 aa
23.6 kDa
No 0
PHB2-201
ENSP00000382362
ENST00000399433
J3KPX7 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0016020 [membrane]
Show all
298 aa
33.2 kDa
No 0
PHB2-202
ENSP00000412856
ENST00000440277
Q99623 [Direct mapping]
Prohibitin-2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007005 [mitochondrion organization]
GO:0007062 [sister chromatid cohesion]
GO:0008022 [protein C-terminus binding]
GO:0009986 [cell surface]
GO:0016363 [nuclear matrix]
GO:0030331 [estrogen receptor binding]
GO:0031536 [positive regulation of exit from mitosis]
GO:0033218 [amide binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
Show all
261 aa
29 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.