Expression of PGAM4 in cancer - Summary

CANCER ATLAS

Gene description

Phosphoglycerate mutase family member 4

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Renal cancer

STAINING SUMMARY

HPA042528	HPA049237

GENE INFORMATION
Gene name	PGAM4 (HGNC Symbol)
Synonyms	dJ1000K24.1, PGAM-B, PGAM1, PGAM3
Description	Phosphoglycerate mutase family member 4 (HGNC Symbol)
Entrez gene summary	This intronless gene appears to have arisen from a retrotransposition event, yet it is thought to be an expressed, protein-coding gene. The encoded protein is a member of the phosphoglycerate mutase family, a set of enzymes that catalyze the transfer of a phosphate group from 3-phosphoglycerate to 2-phosphoglycerate. [provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q21.1
Chromosome location (bp)	77968874 - 77969638
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000226784 (version 83.38)
Entrez gene	441531
UniProt	Q8N0Y7 (UniProt - Inferred from homology)
neXtProt	NX_Q8N0Y7
Antibodypedia	PGAM4 antibodies

PROTEIN BROWSER

PGAM4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGAM4-001 ENSP00000412189 ENST00000458128	Q8N0Y7 [Direct mapping] Probable phosphoglycerate mutase 4 Show all	Enzymes ENZYME proteins Hydrolases Isomerase Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004082 [bisphosphoglycerate mutase activity] GO:0004083 [bisphosphoglycerate 2-phosphatase activity] GO:0004619 [phosphoglycerate mutase activity] GO:0005829 [cytosol] GO:0006094 [gluconeogenesis] GO:0006096 [glycolytic process] GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016868 [intramolecular transferase activity, phosphotransferases] GO:0043456 [regulation of pentose-phosphate shunt] GO:0046538 [2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity] GO:0070062 [extracellular exosome] GO:0097228 [sperm principal piece] GO:1902093 [positive regulation of sperm motility] Show all	254 aa 28.8 kDa	No	0