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PGAM4

GENERAL INFORMATION

Gene name

 PGAM4

Gene description

 Phosphoglycerate mutase family member 4

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 2 antibodies.
HPA042528 , HPA049237
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 PGAM4 (HGNC Symbol)

Synonyms

 dJ1000K24.1, PGAM-B, PGAM1, PGAM3

Description

 Phosphoglycerate mutase family member 4 (HGNC Symbol)

Entrez gene summary

 This intronless gene appears to have arisen from a retrotransposition event, yet it is thought to be an expressed, protein-coding gene. The encoded protein is a member of the phosphoglycerate mutase family, a set of enzymes that catalyze the transfer of a phosphate group from 3-phosphoglycerate to 2-phosphoglycerate. [provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 q21.1

Chromosome location (bp)

 77968874 - 77969638

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000226784 (version 83.38)

Entrez gene

 441531

UniProt

 Q8N0Y7 (UniProt - Inferred from homology)

neXtProt

 NX_Q8N0Y7

Antibodypedia

 PGAM4 antibodies

PROTEIN BROWSER
PGAM4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGAM4-001
ENSP00000412189
ENST00000458128
Q8N0Y7 [Direct mapping]
Probable phosphoglycerate mutase 4
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Enzymes
   ENZYME proteins
   Hydrolases
   Isomerase
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004082 [bisphosphoglycerate mutase activity]
GO:0004083 [bisphosphoglycerate 2-phosphatase activity]
GO:0004619 [phosphoglycerate mutase activity]
GO:0005829 [cytosol]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0043456 [regulation of pentose-phosphate shunt]
GO:0046538 [2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity]
GO:0070062 [extracellular exosome]
GO:0097228 [sperm principal piece]
GO:1902093 [positive regulation of sperm motility]
Show all
 254 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.