Cell atlas - PGAM4 - The Human Protein Atlas

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PGAM4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PGAM4
Gene description	Phosphoglycerate mutase family member 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA042528 , HPA060483
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA042528	CACO-2	Nucleoplasm
HPA042528	PC-3	Nucleoplasm
HPA060483	Hep G2	Nucleoplasm
HPA060483	PC-3	Nucleoplasm
HPA060483	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	PGAM4 (HGNC Symbol)
Synonyms	dJ1000K24.1, PGAM-B, PGAM1, PGAM3
Description	Phosphoglycerate mutase family member 4 (HGNC Symbol)
Entrez gene summary	This intronless gene appears to have arisen from a retrotransposition event, yet it is thought to be an expressed, protein-coding gene. The encoded protein is a member of the phosphoglycerate mutase family, a set of enzymes that catalyze the transfer of a phosphate group from 3-phosphoglycerate to 2-phosphoglycerate. [provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q21.1
Chromosome location (bp)	77968874 - 77969638
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000226784 (version 83.38)
Entrez gene	441531
UniProt	Q8N0Y7 (UniProt - Inferred from homology)
neXtProt	NX_Q8N0Y7
Antibodypedia	PGAM4 antibodies

PROTEIN BROWSER

PGAM4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGAM4-001 ENSP00000412189 ENST00000458128	Q8N0Y7 [Direct mapping] Probable phosphoglycerate mutase 4 Show all	Enzymes ENZYME proteins Hydrolases Isomerase Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004082 [bisphosphoglycerate mutase activity] GO:0004083 [bisphosphoglycerate 2-phosphatase activity] GO:0004619 [phosphoglycerate mutase activity] GO:0005829 [cytosol] GO:0006094 [gluconeogenesis] GO:0006096 [glycolytic process] GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016868 [intramolecular transferase activity, phosphotransferases] GO:0043456 [regulation of pentose-phosphate shunt] GO:0046538 [2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity] GO:0070062 [extracellular exosome] GO:0097228 [sperm principal piece] GO:1902093 [positive regulation of sperm motility] Show all	254 aa 28.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.