Cell atlas - DDOST - The Human Protein Atlas

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DDOST

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	DDOST
Gene description	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA046841
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046841	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	DDOST (HGNC Symbol)
Synonyms	KIAA0115, OST, OST48, WBP1
Description	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	20651767 - 20661544
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000244038 (version 83.38)
Entrez gene	1650
UniProt	P39656 (UniProt - Evidence at protein level)
neXtProt	NX_P39656
Antibodypedia	DDOST antibodies

PROTEIN BROWSER

DDOST-001	DDOST-005	DDOST-006	DDOST-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDOST-001 ENSP00000364188 ENST00000375048	P39656 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004576 [oligosaccharyl transferase activity] GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006412 [translation] GO:0006486 [protein glycosylation] GO:0006487 [protein N-linked glycosylation] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008250 [oligosaccharyltransferase complex] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0034097 [response to cytokine] GO:0042110 [T cell activation] GO:0043231 [intracellular membrane-bounded organelle] GO:0043234 [protein complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] Show all	456 aa 50.8 kDa	Yes	1
DDOST-005 ENSP00000475634 ENST00000464364	U3KQ84 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] Show all	155 aa 17.2 kDa	Yes	0
DDOST-006 ENSP00000473655 ENST00000602624	A0A0C4DGS1 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] Show all	439 aa 48.8 kDa	Yes	1
DDOST-201 ENSP00000399457 ENST00000415136	P39656 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004576 [oligosaccharyl transferase activity] GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006412 [translation] GO:0006486 [protein glycosylation] GO:0006487 [protein N-linked glycosylation] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008250 [oligosaccharyltransferase complex] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0034097 [response to cytokine] GO:0042110 [T cell activation] GO:0043231 [intracellular membrane-bounded organelle] GO:0043234 [protein complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] Show all	456 aa 50.8 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.