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DDOST

GENERAL INFORMATION

Gene name

 DDOST

Gene description

 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression, high expression in glandular cells together with immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity support the protein profile.

Reliability score

 Supported based on 3 antibodies.
HPA046841 , HPA052867 , CAB009746
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DDOST (HGNC Symbol)

Synonyms

 KIAA0115, OST, OST48, WBP1

Description

 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.12

Chromosome location (bp)

 20651767 - 20661544

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000244038 (version 83.38)

Entrez gene

 1650

UniProt

 P39656 (UniProt - Evidence at protein level)

neXtProt

 NX_P39656

Antibodypedia

 DDOST antibodies

PROTEIN BROWSER
DDOST-001
DDOST-005
DDOST-006
DDOST-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDOST-001
ENSP00000364188
ENST00000375048
P39656 [Direct mapping]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004576 [oligosaccharyl transferase activity]
GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006412 [translation]
GO:0006486 [protein glycosylation]
GO:0006487 [protein N-linked glycosylation]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0008250 [oligosaccharyltransferase complex]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0034097 [response to cytokine]
GO:0042110 [T cell activation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
Show all
 456 aa
50.8 kDa 		Yes 1
DDOST-005
ENSP00000475634
ENST00000464364
U3KQ84 [Direct mapping]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
Show all
 155 aa
17.2 kDa 		Yes 0
DDOST-006
ENSP00000473655
ENST00000602624
A0A0C4DGS1 [Direct mapping]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
Show all
 439 aa
48.8 kDa 		Yes 1
DDOST-201
ENSP00000399457
ENST00000415136
P39656 [Direct mapping]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004576 [oligosaccharyl transferase activity]
GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006412 [translation]
GO:0006486 [protein glycosylation]
GO:0006487 [protein N-linked glycosylation]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0008250 [oligosaccharyltransferase complex]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0034097 [response to cytokine]
GO:0042110 [T cell activation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
Show all
 456 aa
50.8 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.