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HBB

GENERAL INFORMATION

Gene name

 HBB

Gene description

 Hemoglobin, beta

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (bone marrow)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Expression in erythrocytes.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images. Tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 2 antibodies.
HPA043234 , CAB009526
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HBB (HGNC Symbol)

Synonyms

 beta-globin, CD113t-C, HBD

Description

 Hemoglobin, beta (HGNC Symbol)

Entrez gene summary

 The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 5225464 - 5229395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000244734 (version 83.38)

Entrez gene

 3043

UniProt

 P68871 (UniProt - Evidence at protein level)

neXtProt

 NX_P68871

Antibodypedia

 HBB antibodies

PROTEIN BROWSER
HBB-001
HBB-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HBB-001
ENSP00000333994
ENST00000335295
P68871 [Direct mapping]
Hemoglobin subunit beta LVV-hemorphin-7 Spinorphin
D9YZU5 [Target identity:100%; Query identity:100%]
Hemoglobin, beta
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005833 [hemoglobin complex]
GO:0006898 [receptor-mediated endocytosis]
GO:0007596 [blood coagulation]
GO:0008217 [regulation of blood pressure]
GO:0010942 [positive regulation of cell death]
GO:0015671 [oxygen transport]
GO:0015701 [bicarbonate transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0030185 [nitric oxide transport]
GO:0030492 [hemoglobin binding]
GO:0031720 [haptoglobin binding]
GO:0031838 [haptoglobin-hemoglobin complex]
GO:0042542 [response to hydrogen peroxide]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0050880 [regulation of blood vessel size]
GO:0051291 [protein heterooligomerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070293 [renal absorption]
GO:0070527 [platelet aggregation]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
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 147 aa
16 kDa 		No 0
HBB-004
ENSP00000369671
ENST00000380315
F8W6P5 [Direct mapping]
Hemoglobin subunit beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005833 [hemoglobin complex]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
Show all
 90 aa
9.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.