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In most cancers, several cases displayed moderate to strong cytoplasmic positivity. Additional membranous staining was observed in a few cases. Gliomas, prostate and gastric cancers were in general weakly stained do negative.
GENE INFORMATION
Gene name
HPR
Synonyms
Description
Haptoglobin-related protein (HGNC Symbol)
Entrez gene summary
This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]