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HPR

GENERAL INFORMATION

Gene name

 HPR

Gene description

 Haptoglobin-related protein

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in liver with distinct positivity in plasma and extracellular matrix.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA047750
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 HPR

Synonyms

Description

 Haptoglobin-related protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]

Chromosome

 16

Cytoband

 q22.2

Chromosome location (bp)

 72063224 - 72077246

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000261701 (version 83.38)

Entrez gene

 3250

UniProt

 P00739 (UniProt - Evidence at transcript level)

neXtProt

 NX_P00739

Antibodypedia

 HPR antibodies

PROTEIN BROWSER
HPR-001
HPR-002
HPR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HPR-001
ENSP00000441828
ENST00000540303
P00739 [Direct mapping]
Haptoglobin-related protein
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Enzymes
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004252 [serine-type endopeptidase activity]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
GO:0006898 [receptor-mediated endocytosis]
GO:0030492 [hemoglobin binding]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 348 aa
39 kDa 		Yes 0
HPR-002
ENSP00000462916
ENST00000561690
J3KTC3 [Direct mapping]
Haptoglobin-related protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 117 aa
13.3 kDa 		Yes 0
HPR-201
ENSP00000349451
ENST00000356967
A0A0A0MRD9 [Direct mapping]
Haptoglobin-related protein
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 281 aa
31.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.