Cell atlas - HPR - The Human Protein Atlas

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HPR

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	HPR
Gene description	Haptoglobin-related protein
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enriched (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047750
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047750	HeLa	Nucleoplasm
	HPA047750	Hep G2	Nucleoplasm
	HPA047750	Hep G2	Vesicles

GENE INFORMATION
Gene name	HPR
Synonyms
Description	Haptoglobin-related protein (HGNC Symbol)
Entrez gene summary	This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
Chromosome	16
Cytoband	q22.2
Chromosome location (bp)	72063224 - 72077246
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000261701 (version 83.38)
Entrez gene	3250
UniProt	P00739 (UniProt - Evidence at transcript level)
neXtProt	NX_P00739
Antibodypedia	HPR antibodies

PROTEIN BROWSER

HPR-001	HPR-002	HPR-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HPR-001 ENSP00000441828 ENST00000540303	P00739 [Direct mapping] Haptoglobin-related protein Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0030492 [hemoglobin binding] GO:0034366 [spherical high-density lipoprotein particle] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	348 aa 39 kDa	Yes	0
HPR-002 ENSP00000462916 ENST00000561690	J3KTC3 [Direct mapping] Haptoglobin-related protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		117 aa 13.3 kDa	Yes	0
HPR-201 ENSP00000349451 ENST00000356967	A0A0A0MRD9 [Direct mapping] Haptoglobin-related protein Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	281 aa 31.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.