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Novel biomarkers for prostate cancer found while defining the prostate specific transcriptome and proteome

To better understand the function of the prostate and diseases associated with it, it is important to explore the molecular constituents that make up the prostate gland.

In a recent study by scientists from the Human Protein Atlas project and colleagues both gene and protein expression profiles were investigated in prostate tissue and compared to 26 other human tissues. The aim was to identify potential prostate specific biomarkers for potential clinical use.

The study identified 203 genes with elevated expression in the prostate, 22 of which showed more than five-times higher expression in the prostate compared to all other tissue types. Among the genes with elevated expression in prostate tissue, two less well known proteins called TMEM79 and ACOXL were identified.

Access the Tissue Atlas data for TMEM79 in normal prostate and in cancer tissue.

Access the Tissue Atlas data for ACOXL in normal prostate and in cancer tissue.

TMEM79 and ACOXL have elevated expression in prostate tissue and may be potential prostate specific biomarkers that could provide assistance in diagnostics.

Visit the human prostate proteome knowledge page.

Read the full analysis of the human prostate proteome here.