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Gene name

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Chromosome

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In atlas

Reliability

Reliability

Reliability

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Method

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Method

Validation

Method

Validation

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Searches

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Cell type

Expression

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Detectable

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CDH1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CDH1

Gene description

Cadherin 1, type 1

Protein class

Cancer-related genes
CD markers
Disease related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (parathyroid gland)
GTEx:Mixed
FANTOM5:Tissue enhanced (small intestine)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in epithelial cells.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 6 antibodies.
HPA004812 , CAB000087 , CAB028364 , CAB072855 , CAB072856 , CAB072857
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION

Gene name

CDH1 (HGNC Symbol)

Synonyms

CD324, UVO, uvomorulin

Description

Cadherin 1, type 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

Chromosome

16

Cytoband

q22.1

Chromosome location (bp)

68737225 - 68835548

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000039068 (version 83.38)

Entrez gene

999

UniProt

P12830 (UniProt - Evidence at protein level)

neXtProt

NX_P12830

Antibodypedia

CDH1 antibodies

PROTEIN BROWSER

CDH1-001
CDH1-004
CDH1-201
CDH1-202
CDH1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDH1-001
ENSP00000261769
ENST00000261769
P12830 [Direct mapping]
Cadherin-1 E-Cad/CTF1 E-Cad/CTF2 E-Cad/CTF3
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007416 [synapse assembly]
GO:0008013 [beta-catenin binding]
GO:0009636 [response to toxic substance]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0012501 [programmed cell death]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016328 [lateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016342 [catenin complex]
GO:0016600 [flotillin complex]
GO:0021983 [pituitary gland development]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030198 [extracellular matrix organization]
GO:0030506 [ankyrin binding]
GO:0030864 [cortical actin cytoskeleton]
GO:0031175 [neuron projection development]
GO:0032794 [GTPase activating protein binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042493 [response to drug]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043296 [apical junction complex]
GO:0045216 [cell-cell junction organization]
GO:0045295 [gamma-catenin binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0070062 [extracellular exosome]
GO:0071285 [cellular response to lithium ion]
GO:0071681 [cellular response to indole-3-methanol]
GO:0072659 [protein localization to plasma membrane]
GO:0090002 [establishment of protein localization to plasma membrane]
Show all
882 aa
97.5 kDa
Yes 1
CDH1-004
ENSP00000414946
ENST00000422392
P12830 [Direct mapping]
Cadherin-1 E-Cad/CTF1 E-Cad/CTF2 E-Cad/CTF3
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008013 [beta-catenin binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0012501 [programmed cell death]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016328 [lateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016342 [catenin complex]
GO:0016600 [flotillin complex]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030198 [extracellular matrix organization]
GO:0030506 [ankyrin binding]
GO:0030864 [cortical actin cytoskeleton]
GO:0032794 [GTPase activating protein binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043296 [apical junction complex]
GO:0045216 [cell-cell junction organization]
GO:0045295 [gamma-catenin binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0070062 [extracellular exosome]
GO:0071285 [cellular response to lithium ion]
GO:0071681 [cellular response to indole-3-methanol]
GO:0072659 [protein localization to plasma membrane]
GO:0090002 [establishment of protein localization to plasma membrane]
Show all
821 aa
90.9 kDa
Yes 1
CDH1-201
ENSP00000481063
ENST00000611625
A0A087WXI5 [Direct mapping]
Cadherin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
903 aa
100 kDa
Yes 1
CDH1-202
ENSP00000478360
ENST00000612417
A0A087WU43 [Direct mapping]
Cadherin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
Show all
647 aa
71.3 kDa
Yes 0
CDH1-203
ENSP00000480664
ENST00000621016
A0A087WX17 [Direct mapping]
Cadherin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
Show all
647 aa
71.4 kDa
Yes 0

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