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Weak to moderate cytoplasmic positivity with additional membranous staining was observed in a majority of malignancies. Endometrial cancers, malignant gliomas and basal cell carcinomas in skin displayed moderate to strong membranous and cytoplasmic staining. Most malignant lymphomas and liver cancers were generally negative.
Most malignant cells showed weak to moderate cytoplasmic staining. Strong positivity was observed in a few malignant gliomas, urothelial cancers and skin cancers.
GENE INFORMATION
Gene name
NFATC3 (HGNC Symbol)
Synonyms
NFAT4, NFATX
Description
Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (HGNC Symbol)
Entrez gene summary
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]