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NFATC3

GENERAL INFORMATION

Gene name

 NFATC3

Gene description

 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and occasional nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA023844 , CAB004514
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NFATC3 (HGNC Symbol)

Synonyms

 NFAT4, NFATX

Description

 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (HGNC Symbol)

Entrez gene summary

 The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 68084751 - 68229259

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072736 (version 83.38)

Entrez gene

 4775

UniProt

 Q12968 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12968

Antibodypedia

 NFATC3 antibodies

PROTEIN BROWSER
NFATC3-001
NFATC3-002
NFATC3-003
NFATC3-016
NFATC3-017
NFATC3-023
NFATC3-024

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFATC3-001
ENSP00000264008
ENST00000349223
Q12968 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 3
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 1065 aa
115.1 kDa 		No 0
NFATC3-002
ENSP00000300659
ENST00000346183
Q12968 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 3
B5B2S1 [Target identity:100%; Query identity:100%]
Nuclear factor of activated T-cells c3 isoform IB-deltaXa; Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3, isoform CRA_b
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001569 [patterning of blood vessels]
GO:0001666 [response to hypoxia]
GO:0001974 [blood vessel remodeling]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0014898 [cardiac muscle hypertrophy in response to stress]
GO:0014902 [myotube differentiation]
GO:0014904 [myotube cell development]
GO:0030217 [T cell differentiation]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045333 [cellular respiration]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048538 [thymus development]
GO:0048741 [skeletal muscle fiber development]
GO:0051145 [smooth muscle cell differentiation]
GO:0055001 [muscle cell development]
GO:0071277 [cellular response to calcium ion]
GO:0071285 [cellular response to lithium ion]
GO:2001256 [regulation of store-operated calcium entry]
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 1075 aa
115.6 kDa 		No 0
NFATC3-003
ENSP00000331324
ENST00000329524
Q12968 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 3
B5B2S0 [Target identity:100%; Query identity:100%]
Nuclear factor of activated T-cells c3 isoform IB-Xa; Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 1068 aa
115.2 kDa 		No 0
NFATC3-016
ENSP00000456379
ENST00000570212
H3BRS1 [Direct mapping]
Nuclear factor of-activated T-cells, cytoplasmic 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 1060 aa
114.2 kDa 		No 0
NFATC3-017
ENSP00000456120
ENST00000562926
H3BR83 [Direct mapping]
Nuclear factor of-activated T-cells, cytoplasmic 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 1053 aa
113.9 kDa 		No 0
NFATC3-023
ENSP00000460533
ENST00000575270
I3L3K7 [Direct mapping]
Nuclear factor of-activated T-cells, cytoplasmic 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 1047 aa
112.8 kDa 		No 0
NFATC3-024
ENSP00000457441
ENST00000565750
H3BU30 [Direct mapping]
Nuclear factor of-activated T-cells, cytoplasmic 3
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 167 aa
18.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.