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NFATC3

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GENERAL INFORMATION

Gene name

 NFATC3

Gene description

 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA050665
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (supported), Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA050665 A-431 Nucleoplasm
Cytosol
HPA050665 U-2 OS Nucleoplasm
Cytosol
HPA050665 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 NFATC3 (HGNC Symbol)

Synonyms

 NFAT4, NFATX

Description

 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (HGNC Symbol)

Entrez gene summary

 The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 68084751 - 68229259

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072736 (version 83.38)

Entrez gene

 4775

UniProt

 Q12968 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12968

Antibodypedia

 NFATC3 antibodies

PROTEIN BROWSER
NFATC3-001
NFATC3-002
NFATC3-003
NFATC3-016
NFATC3-017
NFATC3-023
NFATC3-024

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFATC3-001
ENSP00000264008
ENST00000349223
Q12968 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 3
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 1065 aa
115.1 kDa 		No 0
NFATC3-002
ENSP00000300659
ENST00000346183
Q12968 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 3
B5B2S1 [Target identity:100%; Query identity:100%]
Nuclear factor of activated T-cells c3 isoform IB-deltaXa; Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001569 [patterning of blood vessels]
GO:0001666 [response to hypoxia]
GO:0001974 [blood vessel remodeling]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0014898 [cardiac muscle hypertrophy in response to stress]
GO:0014902 [myotube differentiation]
GO:0014904 [myotube cell development]
GO:0030217 [T cell differentiation]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045333 [cellular respiration]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048538 [thymus development]
GO:0048741 [skeletal muscle fiber development]
GO:0051145 [smooth muscle cell differentiation]
GO:0055001 [muscle cell development]
GO:0071277 [cellular response to calcium ion]
GO:0071285 [cellular response to lithium ion]
GO:2001256 [regulation of store-operated calcium entry]
Show all
 1075 aa
115.6 kDa 		No 0
NFATC3-003
ENSP00000331324
ENST00000329524
Q12968 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 3
B5B2S0 [Target identity:100%; Query identity:100%]
Nuclear factor of activated T-cells c3 isoform IB-Xa; Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 1068 aa
115.2 kDa 		No 0
NFATC3-016
ENSP00000456379
ENST00000570212
H3BRS1 [Direct mapping]
Nuclear factor of-activated T-cells, cytoplasmic 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 1060 aa
114.2 kDa 		No 0
NFATC3-017
ENSP00000456120
ENST00000562926
H3BR83 [Direct mapping]
Nuclear factor of-activated T-cells, cytoplasmic 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 1053 aa
113.9 kDa 		No 0
NFATC3-023
ENSP00000460533
ENST00000575270
I3L3K7 [Direct mapping]
Nuclear factor of-activated T-cells, cytoplasmic 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 1047 aa
112.8 kDa 		No 0
NFATC3-024
ENSP00000457441
ENST00000565750
H3BU30 [Direct mapping]
Nuclear factor of-activated T-cells, cytoplasmic 3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 167 aa
18.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.