Tissue expression of ARHGEF1 - Summary - The Human Protein Atlas

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ARHGEF1

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TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ARHGEF1
Gene description	Rho guanine nucleotide exchange factor (GEF) 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression mainly in lymphoid tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA012924 , CAB009502
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ARHGEF1 (HGNC Symbol)
Synonyms	LBCL2, P115-RHOGEF, SUB1.5
Description	Rho guanine nucleotide exchange factor (GEF) 1 (HGNC Symbol)
Entrez gene summary	Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	41883161 - 41930150
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000076928 (version 83.38)
Entrez gene	9138
UniProt	Q92888 (UniProt - Evidence at protein level)
neXtProt	NX_Q92888
Antibodypedia	ARHGEF1 antibodies

PROTEIN BROWSER

ARHGEF1-001	ARHGEF1-005	ARHGEF1-006	ARHGEF1-007	ARHGEF1-009	ARHGEF1-010	ARHGEF1-015	ARHGEF1-017	ARHGEF1-022	ARHGEF1-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF1-001 ENSP00000344429 ENST00000347545	Q92888 [Direct mapping] Rho guanine nucleotide exchange factor 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007266 [Rho protein signal transduction] GO:0008283 [cell proliferation] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] Show all	879 aa 98.8 kDa	No	0
ARHGEF1-005 ENSP00000346532 ENST00000354532	Q92888 [Direct mapping] Rho guanine nucleotide exchange factor 1 A0A024R0R1 [Target identity:100%; Query identity:100%] Rho guanine nucleotide exchange factor (GEF) 1, isoform CRA_e Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007266 [Rho protein signal transduction] GO:0008283 [cell proliferation] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] Show all	912 aa 102.4 kDa	No	0
ARHGEF1-006 ENSP00000337261 ENST00000337665	Q92888 [Direct mapping] Rho guanine nucleotide exchange factor 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007266 [Rho protein signal transduction] GO:0008283 [cell proliferation] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] Show all	927 aa 104.1 kDa	No	0
ARHGEF1-007 ENSP00000367394 ENST00000378152	Q92888 [Direct mapping] Rho guanine nucleotide exchange factor 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007266 [Rho protein signal transduction] GO:0008283 [cell proliferation] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] Show all	948 aa 105.9 kDa	No	0
ARHGEF1-009 ENSP00000469735 ENST00000599589	M0QYC1 [Direct mapping] Rho guanine nucleotide exchange factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	702 aa 78.5 kDa	No	0
ARHGEF1-010 ENSP00000470715 ENST00000599846	M0QZR4 [Direct mapping] Rho guanine nucleotide exchange factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	968 aa 108.3 kDa	No	0
ARHGEF1-015 ENSP00000470557 ENST00000594521	M0QZH8 [Direct mapping] Rho guanine nucleotide exchange factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	275 aa 30 kDa	No	0
ARHGEF1-017 ENSP00000470042 ENST00000594258	M0QYS3 [Direct mapping] Rho guanine nucleotide exchange factor 1 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	307 aa 34.2 kDa	No	0
ARHGEF1-022 ENSP00000472466 ENST00000595723	M0R2C7 [Direct mapping] Rho guanine nucleotide exchange factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	291 aa 32.8 kDa	No	0
ARHGEF1-024 ENSP00000471942 ENST00000594417	M0R1K8 [Direct mapping] Rho guanine nucleotide exchange factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 13.9 kDa	No	0

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