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DNAJA3

GENERAL INFORMATION

Gene name

 DNAJA3

Gene description

 DnaJ (Hsp40) homolog, subfamily A, member 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA040875 , HPA044229 , CAB016095
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DNAJA3 (HGNC Symbol)

Synonyms

 hTid-1, TID1

Description

 DnaJ (Hsp40) homolog, subfamily A, member 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 4425805 - 4456775

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103423 (version 83.38)

Entrez gene

 9093

UniProt

 Q96EY1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96EY1

Antibodypedia

 DNAJA3 antibodies

PROTEIN BROWSER
DNAJA3-001
DNAJA3-002
DNAJA3-009
DNAJA3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAJA3-001
ENSP00000262375
ENST00000262375
Q96EY1 [Direct mapping]
DnaJ homolog subfamily A member 3, mitochondrial
Q53G26 [Target identity:100%; Query identity:100%]
DnaJ (Hsp40) homolog, subfamily A, member 3 variant; DnaJ (Hsp40) homolog, subfamily A, member 3, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005133 [interferon-gamma receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006264 [mitochondrial DNA replication]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0007005 [mitochondrion organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007528 [neuromuscular junction development]
GO:0007569 [cell aging]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008385 [IkappaB kinase complex]
GO:0009408 [response to heat]
GO:0019897 [extrinsic component of plasma membrane]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0030544 [Hsp70 protein binding]
GO:0030695 [GTPase regulator activity]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031072 [heat shock protein binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031594 [neuromuscular junction]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0033077 [T cell differentiation in thymus]
GO:0033256 [I-kappaB/NF-kappaB complex]
GO:0034341 [response to interferon-gamma]
GO:0042026 [protein refolding]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042645 [mitochondrial nucleoid]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0050821 [protein stabilization]
GO:0051059 [NF-kappaB binding]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0071340 [skeletal muscle acetylcholine-gated channel clustering]
Show all
 480 aa
52.5 kDa 		No 0
DNAJA3-002
ENSP00000347445
ENST00000355296
Q96EY1 [Direct mapping]
DnaJ homolog subfamily A member 3, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005133 [interferon-gamma receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007005 [mitochondrion organization]
GO:0007528 [neuromuscular junction development]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008385 [IkappaB kinase complex]
GO:0009408 [response to heat]
GO:0019897 [extrinsic component of plasma membrane]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0031072 [heat shock protein binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031594 [neuromuscular junction]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0033256 [I-kappaB/NF-kappaB complex]
GO:0034341 [response to interferon-gamma]
GO:0042026 [protein refolding]
GO:0042645 [mitochondrial nucleoid]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0050821 [protein stabilization]
GO:0051059 [NF-kappaB binding]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0071340 [skeletal muscle acetylcholine-gated channel clustering]
Show all
 453 aa
49.6 kDa 		No 0
DNAJA3-009
ENSP00000459088
ENST00000574895
I3L1T6 [Direct mapping]
DnaJ homolog subfamily A member 3, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007005 [mitochondrion organization]
GO:0042026 [protein refolding]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
Show all
 185 aa
20.4 kDa 		No 0
DNAJA3-201
ENSP00000393970
ENST00000431375
Q96EY1 [Direct mapping]
DnaJ homolog subfamily A member 3, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005133 [interferon-gamma receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007005 [mitochondrion organization]
GO:0007528 [neuromuscular junction development]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008385 [IkappaB kinase complex]
GO:0009408 [response to heat]
GO:0019897 [extrinsic component of plasma membrane]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0031072 [heat shock protein binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031594 [neuromuscular junction]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0033256 [I-kappaB/NF-kappaB complex]
GO:0034341 [response to interferon-gamma]
GO:0042026 [protein refolding]
GO:0042645 [mitochondrial nucleoid]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0050821 [protein stabilization]
GO:0051059 [NF-kappaB binding]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0071340 [skeletal muscle acetylcholine-gated channel clustering]
Show all
 300 aa
33.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.