Tissue expression of TMC5 - Summary - The Human Protein Atlas

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TMC5

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TMC5
Gene description	Transmembrane channel-like 5
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (small intestine)
GTEx:	Tissue enhanced (small intestine, salivary gland)
FANTOM5:	Group enriched (small intestine, colon)

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in a few tissues including the intestinal tract. Additional cytoplasmic positivity in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA040810 , HPA042037
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine, salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (small intestine, colon)

GENE INFORMATION
Gene name	TMC5 (HGNC Symbol)
Synonyms	FLJ13593
Description	Transmembrane channel-like 5 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	19410496 - 19499113
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103534 (version 83.38)
Entrez gene	79838
UniProt	Q6UXY8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6UXY8
Antibodypedia	TMC5 antibodies

PROTEIN BROWSER

TMC5-001	TMC5-002	TMC5-004	TMC5-005	TMC5-006	TMC5-007	TMC5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMC5-001 ENSP00000370822 ENST00000381414	Q6UXY8 [Direct mapping] Transmembrane channel-like protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	948 aa 108.1 kDa	No	8
TMC5-002 ENSP00000219821 ENST00000219821	Q6UXY8 [Direct mapping] Transmembrane channel-like protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	760 aa 87.8 kDa	No	9
TMC5-004 ENSP00000456148 ENST00000561503	Q6UXY8 [Direct mapping] Transmembrane channel-like protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	647 aa 75.5 kDa	No	9
TMC5-005 ENSP00000454710 ENST00000564959	H3BN68 [Direct mapping] Transmembrane channel-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	689 aa 80.1 kDa	No	9
TMC5-006 ENSP00000446274 ENST00000542583	Q6UXY8 [Direct mapping] Transmembrane channel-like protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1006 aa 114.8 kDa	No	9
TMC5-007 ENSP00000441227 ENST00000541464	F5GYU8 [Direct mapping] Transmembrane channel-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	954 aa 108.9 kDa	No	8
TMC5-201 ENSP00000379531 ENST00000396229	Q6UXY8 [Direct mapping] Transmembrane channel-like protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1006 aa 114.8 kDa	No	9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.