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CALB1

GENERAL INFORMATION

Gene name

 CALB1

Gene description

 Calbindin 1, 28kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (kidney)
GTEx:Group enriched (kidney, caudate, cerebellum, hypothalamus)
FANTOM5:Tissue enhanced (cerebellum, caudate, kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in Purkinje cells and renal tubules.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA023099 , HPA056734 , CAB002138
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (kidney, caudate, cerebellum, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, caudate, kidney)

GENE INFORMATION

Gene name

 CALB1 (HGNC Symbol)

Synonyms

 CALB

Description

 Calbindin 1, 28kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015]

Chromosome

 8

Cytoband

 q21.3

Chromosome location (bp)

 90058608 - 90095475

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104327 (version 83.38)

Entrez gene

 793

UniProt

 P05937 (UniProt - Evidence at protein level)

neXtProt

 NX_P05937

Antibodypedia

 CALB1 antibodies

PROTEIN BROWSER
CALB1-001
CALB1-007
CALB1-008
CALB1-009
CALB1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CALB1-001
ENSP00000265431
ENST00000265431
P05937 [Direct mapping]
Calbindin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005499 [vitamin D binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007611 [learning or memory]
GO:0007614 [short-term memory]
GO:0007616 [long-term memory]
GO:0007626 [locomotory behavior]
GO:0008270 [zinc ion binding]
GO:0010842 [retina layer formation]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0035502 [metanephric part of ureteric bud development]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0044297 [cell body]
GO:0045202 [synapse]
GO:0048167 [regulation of synaptic plasticity]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0060041 [retina development in camera-type eye]
GO:0070062 [extracellular exosome]
GO:0071310 [cellular response to organic substance]
GO:0072205 [metanephric collecting duct development]
GO:0072221 [metanephric distal convoluted tubule development]
GO:0072286 [metanephric connecting tubule development]
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 261 aa
30 kDa 		No 0
CALB1-007
ENSP00000429246
ENST00000523716
E5RIZ8 [Direct mapping]
Calbindin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0055074 [calcium ion homeostasis]
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 119 aa
14 kDa 		No 0
CALB1-008
ENSP00000429602
ENST00000518457
P05937 [Direct mapping]
Calbindin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005499 [vitamin D binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0007614 [short-term memory]
GO:0007616 [long-term memory]
GO:0008270 [zinc ion binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0043025 [neuronal cell body]
GO:0045202 [synapse]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0070062 [extracellular exosome]
Show all
 204 aa
23.6 kDa 		No 0
CALB1-009
ENSP00000430192
ENST00000514406
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 3 aa
0.4 kDa 		No 0
CALB1-010
ENSP00000430281
ENST00000520613
E5RG14 [Direct mapping]
Calbindin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0055074 [calcium ion homeostasis]
Show all
 102 aa
12 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.