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QKI

GENERAL INFORMATION

Gene name

 QKI

Gene description

 QKI, KH domain containing, RNA binding

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several tissues, most abundant in glial cells of the CNS and placental trophoblasts.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA019123 , CAB022602
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 QKI (HGNC Symbol)

Synonyms

 QK3

Description

 QKI, KH domain containing, RNA binding (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

 6

Cytoband

 q26

Chromosome location (bp)

 163414000 - 163578596

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112531 (version 83.38)

Entrez gene

 9444

UniProt

 Q96PU8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96PU8

Antibodypedia

 QKI antibodies

PROTEIN BROWSER
«
QKI-001
QKI-002
QKI-003
QKI-004
QKI-006
QKI-007
QKI-012
QKI-013
QKI-014
QKI-016
QKI-017
QKI-020
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
QKI-001
ENSP00000355094
ENST00000361752
Q96PU8 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001570 [vasculogenesis]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0007286 [spermatid development]
GO:0008366 [axon ensheathment]
GO:0008380 [RNA splicing]
GO:0010628 [positive regulation of gene expression]
GO:0017124 [SH3 domain binding]
GO:0042552 [myelination]
GO:0042692 [muscle cell differentiation]
GO:0042759 [long-chain fatty acid biosynthetic process]
GO:0044822 [poly(A) RNA binding]
GO:0051028 [mRNA transport]
GO:0061158 [3'-UTR-mediated mRNA destabilization]
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 341 aa
37.7 kDa 		No 0
QKI-002
ENSP00000408775
ENST00000453779
Q96PU8 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0017124 [SH3 domain binding]
GO:0044822 [poly(A) RNA binding]
GO:0051028 [mRNA transport]
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 319 aa
35.1 kDa 		No 0
QKI-003
ENSP00000275262
ENST00000275262
Q96PU8 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0017124 [SH3 domain binding]
GO:0044822 [poly(A) RNA binding]
GO:0051028 [mRNA transport]
Show all
 325 aa
36 kDa 		No 0
QKI-004
ENSP00000375973
ENST00000392127
Q96PU8 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0017124 [SH3 domain binding]
GO:0044822 [poly(A) RNA binding]
GO:0051028 [mRNA transport]
Show all
 319 aa
35.2 kDa 		No 0
QKI-006
ENSP00000354867
ENST00000361195
Q96PU8 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0017124 [SH3 domain binding]
GO:0044822 [poly(A) RNA binding]
GO:0051028 [mRNA transport]
Show all
 333 aa
36.9 kDa 		No 0
QKI-007
ENSP00000408382
ENST00000424802
Q96PU8 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0017124 [SH3 domain binding]
GO:0044822 [poly(A) RNA binding]
GO:0051028 [mRNA transport]
Show all
 317 aa
35.2 kDa 		No 0
QKI-012
ENSP00000443690
ENST00000544436
F5H8C8 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
Show all
 100 aa
11.4 kDa 		No 0
QKI-013
ENSP00000443106
ENST00000537124
F5H5U6 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
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 48 aa
5.5 kDa 		No 0
QKI-014
ENSP00000440599
ENST00000544823
F5GYM3 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
Show all
 170 aa
18.9 kDa 		No 0
QKI-016
ENSP00000440991
ENST00000537041
F5GXS8 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
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 160 aa
18 kDa 		No 0
QKI-017
ENSP00000441773
ENST00000537883
H0YG47 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
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 238 aa
25.8 kDa 		No 0
QKI-020
ENSP00000442848
ENST00000544361
H0YGD6 [Direct mapping]
Protein quaking
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
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 185 aa
19.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.