Fields »
ABOUT
HELP
BLOG
SDC1

GENERAL INFORMATION

Gene name

 SDC1

Gene description

 Syndecan 1

Protein class

 Cancer-related genes
CD markers
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin, esophagus)
GTEx:Tissue enhanced (skin, esophagus)
FANTOM5:Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in several tissues, including esophagus.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA006185 , CAB002424
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin, esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin, esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION

Gene name

 SDC1 (HGNC Symbol)

Synonyms

 CD138, SDC, SYND1, syndecan

Description

 Syndecan 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p24.1

Chromosome location (bp)

 20200797 - 20225433

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115884 (version 83.38)

Entrez gene

 6382

UniProt

 P18827 (UniProt - Evidence at protein level)

neXtProt

 NX_P18827

Antibodypedia

 SDC1 antibodies

PROTEIN BROWSER
SDC1-001
SDC1-002
SDC1-005
SDC1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SDC1-001
ENSP00000254351
ENST00000254351
P18827 [Direct mapping]
Syndecan-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0007603 [phototransduction, visible light]
GO:0008022 [protein C-terminus binding]
GO:0009986 [cell surface]
GO:0016477 [cell migration]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0042157 [lipoprotein metabolic process]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0048627 [myoblast development]
GO:0055002 [striated muscle cell development]
GO:0070062 [extracellular exosome]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903553 [positive regulation of extracellular exosome assembly]
Show all
 310 aa
32.5 kDa 		Yes 1
SDC1-002
ENSP00000384613
ENST00000403076
E9PHH3 [Direct mapping]
Syndecan-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0042060 [wound healing]
Show all
 169 aa
17.8 kDa 		Yes 0
SDC1-005
ENSP00000400773
ENST00000429035
H7C1K4 [Direct mapping]
Syndecan-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0042060 [wound healing]
Show all
 215 aa
22 kDa 		No 0
SDC1-201
ENSP00000370542
ENST00000381150
P18827 [Direct mapping]
Syndecan-1
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001657 [ureteric bud development]
GO:0001948 [glycoprotein binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0006954 [inflammatory response]
GO:0007603 [phototransduction, visible light]
GO:0008022 [protein C-terminus binding]
GO:0009636 [response to toxic substance]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010033 [response to organic substance]
GO:0016477 [cell migration]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0042060 [wound healing]
GO:0042157 [lipoprotein metabolic process]
GO:0042476 [odontogenesis]
GO:0042542 [response to hydrogen peroxide]
GO:0043202 [lysosomal lumen]
GO:0043234 [protein complex]
GO:0044281 [small molecule metabolic process]
GO:0048627 [myoblast development]
GO:0051384 [response to glucocorticoid]
GO:0051591 [response to cAMP]
GO:0051592 [response to calcium ion]
GO:0055002 [striated muscle cell development]
GO:0060009 [Sertoli cell development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0070062 [extracellular exosome]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903553 [positive regulation of extracellular exosome assembly]
Show all
 310 aa
32.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.