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SLC2A1

GENERAL INFORMATION

Gene name

 SLC2A1

Gene description

 Solute carrier family 2 (facilitated glucose transporter), member 1

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (placenta)
GTEx:Expressed in all
FANTOM5:Group enriched (placenta, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression most abundant in endothelial and trophoblastic cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 3 antibodies.
HPA031345 , HPA058494 , CAB002759
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (placenta, retina)

GENE INFORMATION

Gene name

 SLC2A1 (HGNC Symbol)

Synonyms

 CSE, DYT18, DYT9, GLUT, GLUT1, HTLVR

Description

 Solute carrier family 2 (facilitated glucose transporter), member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 42925375 - 42959173

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117394 (version 83.38)

Entrez gene

 6513

UniProt

 P11166 (UniProt - Evidence at protein level)

neXtProt

 NX_P11166

Antibodypedia

 SLC2A1 antibodies

PROTEIN BROWSER
SLC2A1-001
SLC2A1-006
SLC2A1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC2A1-001
ENSP00000416293
ENST00000426263
P11166 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001939 [female pronucleus]
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0005911 [cell-cell junction]
GO:0005975 [carbohydrate metabolic process]
GO:0005989 [lactose biosynthetic process]
GO:0006112 [energy reserve metabolic process]
GO:0006461 [protein complex assembly]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006970 [response to osmotic stress]
GO:0008645 [hexose transport]
GO:0015758 [glucose transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019852 [L-ascorbic acid metabolic process]
GO:0019900 [kinase binding]
GO:0022857 [transmembrane transporter activity]
GO:0022891 [substrate-specific transmembrane transporter activity]
GO:0030496 [midbody]
GO:0030864 [cortical actin cytoskeleton]
GO:0031982 [vesicle]
GO:0033300 [dehydroascorbic acid transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0042149 [cellular response to glucose starvation]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042908 [xenobiotic transport]
GO:0042910 [xenobiotic transporter activity]
GO:0043621 [protein self-association]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0046323 [glucose import]
GO:0050796 [regulation of insulin secretion]
GO:0055056 [D-glucose transmembrane transporter activity]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070837 [dehydroascorbic acid transport]
GO:0072562 [blood microparticle]
GO:1904659 [glucose transmembrane transport]
Show all
 492 aa
54.1 kDa 		No >9
SLC2A1-006
ENSP00000487213
ENST00000475162
A0A0D9SG74 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
Show all
 142 aa
15.2 kDa 		No 4
SLC2A1-013
ENSP00000361578
ENST00000372500
A6NL68 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005351 [sugar:proton symporter activity]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
Show all
 116 aa
12.9 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.