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Normal tissues displayed moderate to strong cytoplasmic positivity and additional membranous staining in a few cases. Skeletal muscle was negative.
HPA043684
Respiratory epithelia and fallopian tube displayed strong cytoplasmic and membranous immunoreactivity. Peripheral nerves, neuroendocrine cells and neuronal cells of CNS except Purkinje cells displayed strong cytoplasmic positivity. Moderate cytoplasmic staining was observed in gastrointestinal tract, thyroid gland, urinary bladder, cells in seminiferous ducts of testis and germinal center cells of lymphoid tissues. Remaining normal tissues were negative.
HPA063394
Normal tissues displayed weak to moderate cytoplasmic staining with additional membranous and nuclear positivity in several tissues. Bronchus was strongly stained.
CAB004621
Most normal cells showed moderate to strong cytoplasmic positivity.
CAB005887
This antibody usually showed a diffuse cytoplasmic staining with variable intensity. Rare cells showed nuclear expression. There was very strong staining in neural tissue and in glandular cells in many organs. Squamous epithelium showed variable staining intensity. Lymphoid cells were strongly positive in germinal centers and weaker staining was seen in small lymphocytes. Strong staining was found in megakaryocytes and some precursors in the bone marrow.
Very strong expression was seen in gliomas and in many lymphomas. Other tumors showed more variable staining intenstity but most samples were positive. There was positivity in stroma in most tumors.
