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GFAP

GENERAL INFORMATION

Gene name

 GFAP

Gene description

 Glial fibrillary acidic protein

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (hypothalamus, hippocampus, caudate)
FANTOM5:Group enriched (hippocampus, brain, caudate, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression of astrocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA056030 , HPA063513 , CAB000039
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hypothalamus, hippocampus, caudate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hippocampus, brain, caudate, cerebellum)

GENE INFORMATION

Gene name

 GFAP (HGNC Symbol)

Synonyms

 FLJ45472

Description

 Glial fibrillary acidic protein (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 44905008 - 44916937

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131095 (version 83.38)

Entrez gene

 2670

UniProt

 P14136 (UniProt - Evidence at protein level)

neXtProt

 NX_P14136

Antibodypedia

 GFAP antibodies

PROTEIN BROWSER
«
GFAP-001
GFAP-002
GFAP-005
GFAP-006
GFAP-008
GFAP-009
GFAP-011
GFAP-015
GFAP-018
GFAP-019
GFAP-021
GFAP-023
GFAP-024
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GFAP-001
ENSP00000253408
ENST00000253408
P14136 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005882 [intermediate filament]
Show all
 432 aa
49.9 kDa 		No 0
GFAP-002
ENSP00000403962
ENST00000435360
P14136 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005882 [intermediate filament]
Show all
 431 aa
49.5 kDa 		No 0
GFAP-005
ENSP00000465320
ENST00000592320
K7EJU1 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 248 aa
28.5 kDa 		No 0
GFAP-006
ENSP00000466163
ENST00000588037
K7ELP4 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 189 aa
21.3 kDa 		No 0
GFAP-008
ENSP00000466598
ENST00000588735
K7EMP8 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 58 aa
6.6 kDa 		No 0
GFAP-009
ENSP00000464795
ENST00000586127
K7EIL2 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 12 aa
1.4 kDa 		No 0
GFAP-011
ENSP00000465624
ENST00000587997
K7EKH6 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 191 aa
22.4 kDa 		No 0
GFAP-015
ENSP00000467530
ENST00000591880
K7EPT8 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 101 aa
11.4 kDa 		No 0
GFAP-018
ENSP00000465629
ENST00000588316
K7EKH9 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 261 aa
29.8 kDa 		No 0
GFAP-019
ENSP00000467397
ENST00000586125
K7EPI4 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 64 aa
7.1 kDa 		No 0
GFAP-021
ENSP00000465565
ENST00000588957
K7EKD1 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 57 aa
6.6 kDa 		No 0
GFAP-023
ENSP00000467106
ENST00000593179
A0A0G2JLI8 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 9 aa
1.1 kDa 		No 0
GFAP-024
ENSP00000468500
ENST00000586793
P14136 [Direct mapping]
Glial fibrillary acidic protein
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005178 [integrin binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005882 [intermediate filament]
GO:0009611 [response to wounding]
GO:0010625 [positive regulation of Schwann cell proliferation]
GO:0010977 [negative regulation of neuron projection development]
GO:0014002 [astrocyte development]
GO:0016020 [membrane]
GO:0019900 [kinase binding]
GO:0030198 [extracellular matrix organization]
GO:0031102 [neuron projection regeneration]
GO:0042995 [cell projection]
GO:0043209 [myelin sheath]
GO:0044297 [cell body]
GO:0045103 [intermediate filament-based process]
GO:0045109 [intermediate filament organization]
GO:0051580 [regulation of neurotransmitter uptake]
GO:0060020 [Bergmann glial cell differentiation]
GO:0060252 [positive regulation of glial cell proliferation]
GO:0060291 [long-term synaptic potentiation]
GO:0097386 [glial cell projection]
GO:0097449 [astrocyte projection]
GO:0097450 [astrocyte end-foot]
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 438 aa
50.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.