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This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000228 [nuclear chromosome] GO:0000278 [mitotic cell cycle] GO:0000287 [magnesium ion binding] GO:0000712 [resolution of meiotic recombination intermediates] GO:0000793 [condensed chromosome] GO:0000819 [sister chromatid segregation] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003918 [DNA topoisomerase type II (ATP-hydrolyzing) activity] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005814 [centriole] GO:0006265 [DNA topological change] GO:0006266 [DNA ligation] GO:0006268 [DNA unwinding involved in DNA replication] GO:0006974 [cellular response to DNA damage stimulus] GO:0007059 [chromosome segregation] GO:0008022 [protein C-terminus binding] GO:0008094 [DNA-dependent ATPase activity] GO:0008144 [drug binding] GO:0008301 [DNA binding, bending] GO:0009330 [DNA topoisomerase complex (ATP-hydrolyzing)] GO:0019035 [viral integration complex] GO:0019899 [enzyme binding] GO:0030261 [chromosome condensation] GO:0030263 [apoptotic chromosome condensation] GO:0040016 [embryonic cleavage] GO:0042752 [regulation of circadian rhythm] GO:0042803 [protein homodimerization activity] GO:0042826 [histone deacetylase binding] GO:0043065 [positive regulation of apoptotic process] GO:0043130 [ubiquitin binding] GO:0043234 [protein complex] GO:0044774 [mitotic DNA integrity checkpoint] GO:0044822 [poly(A) RNA binding] GO:0045070 [positive regulation of viral genome replication] GO:0045870 [positive regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048511 [rhythmic process]
