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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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PARP1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PARP1

Gene description

Poly (ADP-ribose) polymerase 1

Protein class

Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in all tissues, most abundant in lymphoid cells.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Two antibodies recognize cleaved forms of the protein and therefore show a different and more restricted expression pattern.

Reliability score

Supported based on 6 antibodies.
HPA045168 , CAB000147 , CAB003839 , CAB003840 , CAB075726 , CAB075727
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

PARP1 (HGNC Symbol)

Synonyms

ADPRT, PARP, PPOL

Description

Poly (ADP-ribose) polymerase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q42.12

Chromosome location (bp)

226360691 - 226408079

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143799 (version 83.38)

Entrez gene

142

UniProt

P09874 (UniProt - Evidence at protein level)

neXtProt

NX_P09874

Antibodypedia

PARP1 antibodies

PROTEIN BROWSER

PARP1-001
PARP1-003
PARP1-005
PARP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PARP1-001
ENSP00000355759
ENST00000366794
P09874 [Direct mapping]
Poly [ADP-ribose] polymerase 1
A0A024R3T8 [Target identity:100%; Query identity:100%]
Poly (ADP-ribose) polymerase family, member 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003950 [NAD+ ADP-ribosyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0006259 [DNA metabolic process]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006471 [protein ADP-ribosylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007005 [mitochondrion organization]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0016020 [membrane]
GO:0016540 [protein autoprocessing]
GO:0016925 [protein sumoylation]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030225 [macrophage differentiation]
GO:0032042 [mitochondrial DNA metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034599 [cellular response to oxidative stress]
GO:0036211 [protein modification process]
GO:0040009 [regulation of growth rate]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0042802 [identical protein binding]
GO:0042826 [histone deacetylase binding]
GO:0043234 [protein complex]
GO:0043504 [mitochondrial DNA repair]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0047485 [protein N-terminus binding]
GO:0048148 [behavioral response to cocaine]
GO:0051287 [NAD binding]
GO:0060391 [positive regulation of SMAD protein import into nucleus]
GO:0070212 [protein poly-ADP-ribosylation]
GO:0070412 [R-SMAD binding]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071451 [cellular response to superoxide]
GO:1903516 [regulation of single strand break repair]
GO:1903827 [regulation of cellular protein localization]
GO:1990404 [protein ADP-ribosylase activity]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
Show all
1014 aa
113.1 kDa
No 0
PARP1-003
ENSP00000355755
ENST00000366790
Q5VX85 [Direct mapping]
Poly [ADP-ribose] polymerase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
Show all
155 aa
17.3 kDa
No 0
PARP1-005
ENSP00000355757
ENST00000366792
Q5VX84 [Direct mapping]
Poly [ADP-ribose] polymerase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
Show all
108 aa
12.2 kDa
No 0
PARP1-201
ENSP00000485852
ENST00000629232
Q5VX84 [Direct mapping]
Poly [ADP-ribose] polymerase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0008270 [zinc ion binding]
Show all
108 aa
12.2 kDa
No 0

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