Expression of LBR in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Lamin B receptor

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Stomach cancer

STAINING SUMMARY

HPA049840

GENE INFORMATION
Gene name	LBR (HGNC Symbol)
Synonyms	DHCR14B, TDRD18
Description	Lamin B receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q42.12
Chromosome location (bp)	225401502 - 225428925
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143815 (version 83.38)
Entrez gene	3930
UniProt	Q14739 (UniProt - Evidence at protein level)
neXtProt	NX_Q14739
Antibodypedia	LBR antibodies

PROTEIN BROWSER

LBR-001	LBR-002	LBR-003	LBR-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LBR-001 ENSP00000272163 ENST00000272163	Q14739 [Direct mapping] Lamin-B receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005639 [integral component of nuclear inner membrane] GO:0006695 [cholesterol biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0055114 [oxidation-reduction process] GO:0070087 [chromo shadow domain binding] Show all	615 aa 70.7 kDa	No	9
LBR-002 ENSP00000388059 ENST00000425080	C9JXK0 [Direct mapping] Lamin-B receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0031965 [nuclear membrane] Show all	213 aa 24.3 kDa	No	0
LBR-003 ENSP00000416554 ENST00000421383	C9JES9 [Direct mapping] Lamin-B receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.9 kDa	No	0
LBR-201 ENSP00000339883 ENST00000338179	Q14739 [Direct mapping] Lamin-B receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005639 [integral component of nuclear inner membrane] GO:0006695 [cholesterol biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0055114 [oxidation-reduction process] GO:0070087 [chromo shadow domain binding] Show all	615 aa 70.7 kDa	No	9