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LBR

GENERAL INFORMATION

Gene name

 LBR

Gene description

 Lamin B receptor

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear membrane expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA049840
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LBR (HGNC Symbol)

Synonyms

 DHCR14B, TDRD18

Description

 Lamin B receptor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.12

Chromosome location (bp)

 225401502 - 225428925

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143815 (version 83.38)

Entrez gene

 3930

UniProt

 Q14739 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14739

Antibodypedia

 LBR antibodies

PROTEIN BROWSER
LBR-001
LBR-002
LBR-003
LBR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LBR-001
ENSP00000272163
ENST00000272163
Q14739 [Direct mapping]
Lamin-B receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005521 [lamin binding]
GO:0005635 [nuclear envelope]
GO:0005639 [integral component of nuclear inner membrane]
GO:0006695 [cholesterol biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor]
GO:0031965 [nuclear membrane]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0055114 [oxidation-reduction process]
GO:0070087 [chromo shadow domain binding]
Show all
 615 aa
70.7 kDa 		No 9
LBR-002
ENSP00000388059
ENST00000425080
C9JXK0 [Direct mapping]
Lamin-B receptor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0031965 [nuclear membrane]
Show all
 213 aa
24.3 kDa 		No 0
LBR-003
ENSP00000416554
ENST00000421383
C9JES9 [Direct mapping]
Lamin-B receptor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 51 aa
5.9 kDa 		No 0
LBR-201
ENSP00000339883
ENST00000338179
Q14739 [Direct mapping]
Lamin-B receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005521 [lamin binding]
GO:0005635 [nuclear envelope]
GO:0005639 [integral component of nuclear inner membrane]
GO:0006695 [cholesterol biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor]
GO:0031965 [nuclear membrane]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0055114 [oxidation-reduction process]
GO:0070087 [chromo shadow domain binding]
Show all
 615 aa
70.7 kDa 		No 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.