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SST

GENERAL INFORMATION

Gene name

 SST

Gene description

 Somatostatin

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (duodenum, stomach, cerebral cortex)
GTEx:Tissue enhanced (hypothalamus, stomach, pancreas)
FANTOM5:Tissue enhanced (pancreas, colon, caudate, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in islets of Langerhans and enteroendocrine cells in the gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA019472 , CAB000075
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (duodenum, stomach, cerebral cortex)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0100200300400TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hypothalamus, stomach, pancreas)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin050100150200250300350RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pancreas, colon, caudate, small intestine)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0200400600800Tags Per Million

GENE INFORMATION

Gene name

 SST (HGNC Symbol)

Synonyms

 SMST

Description

 Somatostatin (HGNC Symbol)

Entrez gene summary

 The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q27.3

Chromosome location (bp)

 187668906 - 187670399

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157005 (version 83.38)

Entrez gene

 6750

UniProt

 P61278 (UniProt - Evidence at protein level)

neXtProt

 NX_P61278

Antibodypedia

 SST antibodies

PROTEIN BROWSER
SST-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SST-001
ENSP00000287641
ENST00000287641
P61278 [Direct mapping]
Somatostatin Somatostatin-28 Somatostatin-14
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
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GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006972 [hyperosmotic response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0007584 [response to nutrient]
GO:0007586 [digestion]
GO:0008285 [negative regulation of cell proliferation]
GO:0008628 [hormone-mediated apoptotic signaling pathway]
GO:0009408 [response to heat]
GO:0010243 [response to organonitrogen compound]
GO:0010447 [response to acidic pH]
GO:0030334 [regulation of cell migration]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043200 [response to amino acid]
GO:0048545 [response to steroid hormone]
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 116 aa
12.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.