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Chromosome

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Reliability

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Method

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Method

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Searches

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Detectable

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CDH2
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CDH2

Gene description

Cadherin 2, type 1, N-cadherin (neuronal)

Protein class

CD markers
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (heart muscle, parathyroid gland)
GTEx:Tissue enhanced (heart muscle, adrenal gland)
FANTOM5:Tissue enhanced (heart muscle, testis)

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in selected tissues, most abundant in liver, kidney, adrenal gland, testis and intercalated discs in heart.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA058574 , CAB000141 , CAB018580
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, adrenal gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, testis)

GENE INFORMATION

Gene name

CDH2 (HGNC Symbol)

Synonyms

CD325, CDHN, NCAD

Description

Cadherin 2, type 1, N-cadherin (neuronal) (HGNC Symbol)

Entrez gene summary

This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]

Chromosome

18

Cytoband

q12.1

Chromosome location (bp)

27950966 - 28177446

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170558 (version 83.38)

Entrez gene

1000

UniProt

P19022 (UniProt - Evidence at protein level)

neXtProt

NX_P19022

Antibodypedia

CDH2 antibodies

PROTEIN BROWSER

CDH2-001
CDH2-002
CDH2-003
CDH2-004
CDH2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDH2-001
ENSP00000269141
ENST00000269141
P19022 [Direct mapping]
Cadherin-2
A0A024RC42 [Target identity:100%; Query identity:100%]
Cadherin 2, type 1, N-cadherin (Neuronal), isoform CRA_b
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005913 [cell-cell adherens junction]
GO:0005916 [fascia adherens]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007416 [synapse assembly]
GO:0008013 [beta-catenin binding]
GO:0010001 [glial cell differentiation]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0021537 [telencephalon development]
GO:0021987 [cerebral cortex development]
GO:0030027 [lamellipodium]
GO:0030864 [cortical actin cytoskeleton]
GO:0031641 [regulation of myelination]
GO:0032403 [protein complex binding]
GO:0032880 [regulation of protein localization]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0042692 [muscle cell differentiation]
GO:0043234 [protein complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0044331 [cell-cell adhesion mediated by cadherin]
GO:0044853 [plasma membrane raft]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0045294 [alpha-catenin binding]
GO:0045295 [gamma-catenin binding]
GO:0048514 [blood vessel morphogenesis]
GO:0048854 [brain morphogenesis]
GO:0048872 [homeostasis of number of cells]
GO:0050770 [regulation of axonogenesis]
GO:0050998 [nitric-oxide synthase binding]
GO:0051146 [striated muscle cell differentiation]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051291 [protein heterooligomerization]
GO:0060019 [radial glial cell differentiation]
GO:0060563 [neuroepithelial cell differentiation]
GO:0070062 [extracellular exosome]
GO:0070445 [regulation of oligodendrocyte progenitor proliferation]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097118 [neuroligin clustering involved in postsynaptic membrane assembly]
GO:0097150 [neuronal stem cell population maintenance]
GO:1902897 [regulation of postsynaptic density protein 95 clustering]
GO:2000809 [positive regulation of synaptic vesicle clustering]
Show all
906 aa
99.8 kDa
Yes 1
CDH2-002
ENSP00000411360
ENST00000418492
C9J8J8 [Direct mapping]
Cadherin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
Show all
191 aa
21.9 kDa
No 0
CDH2-003
ENSP00000382312
ENST00000399380
P19022 [Direct mapping]
Cadherin-2
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0008013 [beta-catenin binding]
GO:0010001 [glial cell differentiation]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016342 [catenin complex]
GO:0030027 [lamellipodium]
GO:0030864 [cortical actin cytoskeleton]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042692 [muscle cell differentiation]
GO:0044331 [cell-cell adhesion mediated by cadherin]
GO:0045216 [cell-cell junction organization]
GO:0045294 [alpha-catenin binding]
GO:0045295 [gamma-catenin binding]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0070062 [extracellular exosome]
GO:0097150 [neuronal stem cell population maintenance]
Show all
875 aa
97 kDa
No 1
CDH2-004
ENSP00000414269
ENST00000413878
C9JMH2 [Direct mapping]
Cadherin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
Show all
73 aa
8.5 kDa
No 0
CDH2-005
ENSP00000412120
ENST00000430882
C9J126 [Direct mapping]
Cadherin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
Show all
120 aa
13.8 kDa
No 0

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