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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CALB2
  • premium

    TISSUE

  • premium

    CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Calbindin 2

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA007305
HPA007306
CAB000106

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Lymphomas showed moderate to strong staining. Most other malignancies showed weak or negative staining.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic staining was observed in most malignancies. A few cases of skin cancers showed strong cytoplasmic and nuclear staining.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All malignant cells were negative.

GENE INFORMATION

Gene name

CALB2 (HGNC Symbol)

Synonyms

CAL2

Description

Calbindin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Chromosome

16

Cytoband

q22.2

Chromosome location (bp)

71358713 - 71390438

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172137 (version 83.38)

Entrez gene

794

UniProt

P22676 (UniProt - Evidence at transcript level)

neXtProt

NX_P22676

Antibodypedia

CALB2 antibodies

PROTEIN BROWSER

CALB2-001
CALB2-003
CALB2-006
CALB2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CALB2-001
ENSP00000307508
ENST00000302628
P22676 [Direct mapping]
Calretinin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005921 [gap junction]
GO:0043005 [neuron projection]
GO:0043195 [terminal bouton]
GO:0045202 [synapse]
GO:0051480 [cytosolic calcium ion homeostasis]
Show all
271 aa
31.5 kDa
No 0
CALB2-003
ENSP00000454467
ENST00000490520
H3BMN5 [Direct mapping]
Calretinin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
158 aa
18.4 kDa
No 0
CALB2-006
ENSP00000454639
ENST00000562305
H3BN14 [Direct mapping]
Calretinin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
235 aa
27.2 kDa
No 0
CALB2-201
ENSP00000340294
ENST00000349553
A6NER6 [Direct mapping]
Calbindin 2, 29kDa (Calretinin), isoform CRA_b; Calretinin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
Show all
192 aa
22.2 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.