Expression of CALB2 in cancer - Summary - The Human Protein Atlas

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CALB2

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TISSUE

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CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

Calbindin 2

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA007305	HPA007306	CAB000106

GENE INFORMATION
Gene name	CALB2 (HGNC Symbol)
Synonyms	CAL2
Description	Calbindin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Chromosome	16
Cytoband	q22.2
Chromosome location (bp)	71358713 - 71390438
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172137 (version 83.38)
Entrez gene	794
UniProt	P22676 (UniProt - Evidence at transcript level)
neXtProt	NX_P22676
Antibodypedia	CALB2 antibodies

PROTEIN BROWSER

CALB2-001	CALB2-003	CALB2-006	CALB2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CALB2-001 ENSP00000307508 ENST00000302628	P22676 [Direct mapping] Calretinin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005921 [gap junction] GO:0043005 [neuron projection] GO:0043195 [terminal bouton] GO:0045202 [synapse] GO:0051480 [cytosolic calcium ion homeostasis] Show all	271 aa 31.5 kDa	No	0
CALB2-003 ENSP00000454467 ENST00000490520	H3BMN5 [Direct mapping] Calretinin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	158 aa 18.4 kDa	No	0
CALB2-006 ENSP00000454639 ENST00000562305	H3BN14 [Direct mapping] Calretinin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	235 aa 27.2 kDa	No	0
CALB2-201 ENSP00000340294 ENST00000349553	A6NER6 [Direct mapping] Calbindin 2, 29kDa (Calretinin), isoform CRA_b; Calretinin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] Show all	192 aa 22.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.