Cell atlas - CALB2 - The Human Protein Atlas

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CALB2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	CALB2
Gene description	Calbindin 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (HMC-1, HEL, U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Mouse	Localized to the Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA007305 , HPA007306
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, HEL, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA007305	A-431	Cytosol
HPA007305	U-2 OS	Cytosol
HPA007305	U-251 MG	No staining
HPA007306	A-431	Cytosol
HPA007306	U-2 OS	Cytosol
HPA007306	U-251 MG	Cytosol

MOUSE CELLS

Main location

Cytosol

Mouse gene

ENSMUSG00000003657 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA007306	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	CALB2 (HGNC Symbol)
Synonyms	CAL2
Description	Calbindin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Chromosome	16
Cytoband	q22.2
Chromosome location (bp)	71358713 - 71390438
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172137 (version 83.38)
Entrez gene	794
UniProt	P22676 (UniProt - Evidence at transcript level)
neXtProt	NX_P22676
Antibodypedia	CALB2 antibodies

PROTEIN BROWSER

CALB2-001	CALB2-003	CALB2-006	CALB2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CALB2-001 ENSP00000307508 ENST00000302628	P22676 [Direct mapping] Calretinin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005921 [gap junction] GO:0043005 [neuron projection] GO:0043195 [terminal bouton] GO:0045202 [synapse] GO:0051480 [cytosolic calcium ion homeostasis] Show all	271 aa 31.5 kDa	No	0
CALB2-003 ENSP00000454467 ENST00000490520	H3BMN5 [Direct mapping] Calretinin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	158 aa 18.4 kDa	No	0
CALB2-006 ENSP00000454639 ENST00000562305	H3BN14 [Direct mapping] Calretinin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	235 aa 27.2 kDa	No	0
CALB2-201 ENSP00000340294 ENST00000349553	A6NER6 [Direct mapping] Calbindin 2, 29kDa (Calretinin), isoform CRA_b; Calretinin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] Show all	192 aa 22.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.