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S100A4

GENERAL INFORMATION

Gene name

 S100A4

Gene description

 S100 calcium binding protein A4

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in infiltrating immune cells in all tissues. Highest levels in urinary bladder, lymphoid tissues and lung.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 6 antibodies.
HPA007973 , CAB002618 , CAB027387 , CAB058698 , CAB068227 , CAB068228
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 S100A4 (HGNC Symbol)

Synonyms

 18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98

Description

 S100 calcium binding protein A4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153543613 - 153550136

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196154 (version 83.38)

Entrez gene

 6275

UniProt

 P26447 (UniProt - Evidence at protein level)

neXtProt

 NX_P26447

Antibodypedia

 S100A4 antibodies

PROTEIN BROWSER
S100A4-001
S100A4-002
S100A4-003
S100A4-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
S100A4-001
ENSP00000357705
ENST00000368716
P26447 [Direct mapping]
Protein S100-A4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044822 [poly(A) RNA binding]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050786 [RAGE receptor binding]
GO:0070062 [extracellular exosome]
Show all
 101 aa
11.7 kDa 		No 0
S100A4-002
ENSP00000346294
ENST00000354332
P26447 [Direct mapping]
Protein S100-A4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050786 [RAGE receptor binding]
GO:0070062 [extracellular exosome]
Show all
 101 aa
11.7 kDa 		No 0
S100A4-003
ENSP00000357704
ENST00000368715
P26447 [Direct mapping]
Protein S100-A4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050786 [RAGE receptor binding]
GO:0070062 [extracellular exosome]
Show all
 101 aa
11.7 kDa 		No 0
S100A4-006
ENSP00000357703
ENST00000368714
P26447 [Direct mapping]
Protein S100-A4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050786 [RAGE receptor binding]
GO:0070062 [extracellular exosome]
Show all
 101 aa
11.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.