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Method

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Searches

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Detectable

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CTSA

Gene description

Cathepsin A

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous granular cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA031068 , CAB024930
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin050100150200250TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0100200300400RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0100200300400Tags Per Million

GENE INFORMATION

Gene name

CTSA (HGNC Symbol)

Synonyms

GSL, PPGB

Description

Cathepsin A (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

45890144 - 45898820

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000064601 (version 83.38)

Entrez gene

5476

UniProt

P10619 (UniProt - Evidence at protein level)

neXtProt

NX_P10619

Antibodypedia

CTSA antibodies

PROTEIN BROWSER

CTSA-001
CTSA-004
CTSA-006
CTSA-012
CTSA-016
CTSA-020

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSA-001
ENSP00000361562
ENST00000372484
X6R8A1 [Direct mapping]
Carboxypeptidase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0006508 [proteolysis]
Show all
498 aa
56.2 kDa
Yes 0
CTSA-004
ENSP00000191018
ENST00000191018
P10619 [Direct mapping]
Lysosomal protective protein Lysosomal protective protein 32 kDa chain Lysosomal protective protein 20 kDa chain
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005654 [nucleoplasm]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006508 [proteolysis]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006886 [intracellular protein transport]
GO:0008047 [enzyme activator activity]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043085 [positive regulation of catalytic activity]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:1904714 [regulation of chaperone-mediated autophagy]
Show all
480 aa
54.5 kDa
Yes 0
CTSA-006
ENSP00000346952
ENST00000354880
X6R5C5 [Direct mapping]
Carboxypeptidase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
Show all
481 aa
54.3 kDa
Yes 0
CTSA-012
ENSP00000361537
ENST00000372459
P10619 [Direct mapping]
Lysosomal protective protein Lysosomal protective protein 32 kDa chain Lysosomal protective protein 20 kDa chain
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005654 [nucleoplasm]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006508 [proteolysis]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006886 [intracellular protein transport]
GO:0008047 [enzyme activator activity]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043085 [positive regulation of catalytic activity]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:1904714 [regulation of chaperone-mediated autophagy]
Show all
480 aa
54.5 kDa
Yes 0
CTSA-016
ENSP00000475524
ENST00000607482
U3KQ41 [Direct mapping]
Lysosomal protective protein
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
Show all
110 aa
12 kDa
Yes 0
CTSA-020
ENSP00000408533
ENST00000419493
Q5JZH0 [Direct mapping]
Lysosomal protective protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
Show all
202 aa
22.2 kDa
No 0

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The Human Protein Atlas project is funded
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