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CTSA

GENERAL INFORMATION

Gene name

 CTSA

Gene description

 Cathepsin A

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous granular cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA031068 , CAB024930
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CTSA (HGNC Symbol)

Synonyms

 GSL, PPGB

Description

 Cathepsin A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015]

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 45890144 - 45898820

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000064601 (version 83.38)

Entrez gene

 5476

UniProt

 P10619 (UniProt - Evidence at protein level)

neXtProt

 NX_P10619

Antibodypedia

 CTSA antibodies

PROTEIN BROWSER
CTSA-001
CTSA-004
CTSA-006
CTSA-012
CTSA-016
CTSA-020

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTSA-001
ENSP00000361562
ENST00000372484
X6R8A1 [Direct mapping]
Carboxypeptidase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0006508 [proteolysis]
Show all
 498 aa
56.2 kDa 		Yes 0
CTSA-004
ENSP00000191018
ENST00000191018
P10619 [Direct mapping]
Lysosomal protective protein Lysosomal protective protein 32 kDa chain Lysosomal protective protein 20 kDa chain
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005654 [nucleoplasm]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006508 [proteolysis]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006886 [intracellular protein transport]
GO:0008047 [enzyme activator activity]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043085 [positive regulation of catalytic activity]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:1904714 [regulation of chaperone-mediated autophagy]
Show all
 480 aa
54.5 kDa 		Yes 0
CTSA-006
ENSP00000346952
ENST00000354880
X6R5C5 [Direct mapping]
Carboxypeptidase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
Show all
 481 aa
54.3 kDa 		Yes 0
CTSA-012
ENSP00000361537
ENST00000372459
P10619 [Direct mapping]
Lysosomal protective protein Lysosomal protective protein 32 kDa chain Lysosomal protective protein 20 kDa chain
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005654 [nucleoplasm]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006508 [proteolysis]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006886 [intracellular protein transport]
GO:0008047 [enzyme activator activity]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043085 [positive regulation of catalytic activity]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:1904714 [regulation of chaperone-mediated autophagy]
Show all
 480 aa
54.5 kDa 		Yes 0
CTSA-016
ENSP00000475524
ENST00000607482
U3KQ41 [Direct mapping]
Lysosomal protective protein
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
Show all
 110 aa
12 kDa 		Yes 0
CTSA-020
ENSP00000408533
ENST00000419493
Q5JZH0 [Direct mapping]
Lysosomal protective protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
Show all
 202 aa
22.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.