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SDHA
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SDHA

Gene description

Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Protein class

Citric acid cycle related proteins
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA041981 , CAB034929
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin050100150200250TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin050100150200RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200250300Tags Per Million

GENE INFORMATION

Gene name

SDHA (HGNC Symbol)

Synonyms

FP, SDH2, SDHF

Description

Succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (HGNC Symbol)

Entrez gene summary

This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Chromosome

5

Cytoband

p15.33

Chromosome location (bp)

218241 - 256700

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000073578 (version 83.38)

Entrez gene

6389

UniProt

P31040 (UniProt - Evidence at protein level)

neXtProt

NX_P31040

Antibodypedia

SDHA antibodies

PROTEIN BROWSER

SDHA-001
SDHA-002
SDHA-004
SDHA-017
SDHA-018
SDHA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SDHA-001
ENSP00000264932
ENST00000264932
P31040 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
A0A024QZ30 [Target identity:100%; Query identity:100%]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000104 [succinate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)]
GO:0006099 [tricarboxylic acid cycle]
GO:0006105 [succinate metabolic process]
GO:0007399 [nervous system development]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0016491 [oxidoreductase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0022900 [electron transport chain]
GO:0022904 [respiratory electron transport chain]
GO:0043209 [myelin sheath]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
664 aa
72.7 kDa
No 0
SDHA-002
ENSP00000426514
ENST00000504309
D6RFM5 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006099 [tricarboxylic acid cycle]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0016491 [oxidoreductase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0022900 [electron transport chain]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
583 aa
63.6 kDa
No 0
SDHA-004
ENSP00000427703
ENST00000510361
P31040 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000104 [succinate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)]
GO:0006099 [tricarboxylic acid cycle]
GO:0006105 [succinate metabolic process]
GO:0007399 [nervous system development]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0016491 [oxidoreductase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0022900 [electron transport chain]
GO:0022904 [respiratory electron transport chain]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
616 aa
67.3 kDa
No 0
SDHA-017
ENSP00000422404
ENST00000515815
H0Y8X1 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Show all
   SignalP predicted secreted proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
126 aa
13.5 kDa
No 0
SDHA-018
ENSP00000421911
ENST00000509564
H0Y8S2 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
101 aa
11.1 kDa
No 0
SDHA-201
ENSP00000484230
ENST00000617470
A0A087X1I3 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
519 aa
56.7 kDa
No 0

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