Tissue expression of CHGB - Summary - The Human Protein Atlas

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CHGB

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CHGB
Gene description	Chromogranin B
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (adrenal gland)
GTEx:	Group enriched (pituitary gland, cerebellum, adrenal gland)
FANTOM5:	Group enriched (pituitary gland, cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in adrenal medulla, islets of Langerhans, enteroendocrine cells and subsets of neuronal cells the CNS.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA008759 , HPA012602 , CAB009403
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (pituitary gland, cerebellum, adrenal gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (pituitary gland, cerebellum)

GENE INFORMATION
Gene name	CHGB (HGNC Symbol)
Synonyms	SCG1, SgI
Description	Chromogranin B (HGNC Symbol)
Entrez gene summary	This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
Chromosome	20
Cytoband	p12.3
Chromosome location (bp)	5911430 - 5925361
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089199 (version 83.38)
Entrez gene	1114
UniProt	P05060 (UniProt - Evidence at protein level)
neXtProt	NX_P05060
Antibodypedia	CHGB antibodies

PROTEIN BROWSER

CHGB-001	CHGB-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHGB-001 ENSP00000368244 ENST00000378961	P05060 [Direct mapping] Secretogranin-1 PE-11 GAWK peptide CCB peptide Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0030141 [secretory granule] Show all	677 aa 78.3 kDa	Yes	0
CHGB-002 ENSP00000416643 ENST00000455042	A0A0A0MT66 [Direct mapping] Secretogranin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030141 [secretory granule] Show all	289 aa 32.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.